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ProteomicsEGFR inhibitor-resistant lung cancers exhibit collateral sensitivity to a covalent, cysteine-independentKEAP1 oligomerizing molecular bridge
Targeted therapies have revolutionized cancer care. Unfortunately, most patients develop refractory, multifocal resistance to these therapies within a matter of months. Here, we demonstrate that the evolution of resistance to EGFR inhibitors in EGFR-mutant non-small cell lung cancer endows cells wit...
ORGANISM(S): Homo sapiens (Human) 
2025-12-07 | PXD071547 | Pride
Keap1 Mcb-613 Egfr-mutant non-small cell lung cancer 
UnknownThe molecular basis for water taste in Drosophila.
Not available
S-EPMC2865571 | biostudies-literature
UnknownRecurrent dominant mutations affecting two adjacent residues in the motor domain of the monomeric kinesin KIF22 result in skeletal dysplasia and joint laxity.
Not available
S-EPMC3234368 | biostudies-literature
TranscriptomicsEffect of enforced BMP4 expression on gene expression profile of 4T1.2 whole primary murine mammary tumours
BMP4 is down-regulated in metastatic human and murine mammary tumours. Here we determined the effect of ectopic mouse Bmp4 re-expression on global gene expression patterns in orthotopic primary mammary tumours in syngeneic Balb/c mice. Breast cancer is a major cause of cancer related death in women,...
ORGANISM(S): Mus musculus 
2014-06-01 | E-GEOD-51632 | biostudies-arrayexpress
UnknownA resilient and connected network of sites to sustain biodiversity under a changing climate.
Not available
S-EPMC9963216 | biostudies-literature
UnknownBasolateral Amygdala Corticotrophin Releasing Factor Receptor 2 Interacts with Nonmuscle Myosin II to Destabilize Memory.
Not available
S-EPMC10245849 | biostudies-literature
UnknownEvolution of late-stage metastatic melanoma is dominated by aneuploidy and whole genome doubling.
Not available
S-EPMC7933255 | biostudies-literature
UnknownThe QuinteT Recruitment Intervention supported five randomized trials to recruit to target: a mixed-methods evaluation.
Not available
S-EPMC6355457 | biostudies-literature
UnknownWhite matter microstructure and functional connectivity in the brains of infants with Turner syndrome.
Not available
S-EPMC11387115 | biostudies-literature
UnknownDelayed Diagnosis and Complications of Predominantly Antibody Deficiencies in a Cohort of Australian Adults.
Not available
S-EPMC5960671 | biostudies-literature
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