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UnknownHepatic MDM2 Causes Metabolic Associated Fatty Liver Disease by Blocking Triglyceride-VLDL Secretion via ApoB Degradation.
Not available
S-EPMC9284139 | biostudies-literature
ProteomicsAdipose MDM2 regulates systemic insulin sensitivity through nuclear import of MORC2 and the PPARγ cofactor LIPIN1
The intimate association between obesity and type II diabetes urges for a deeper understanding of adipocyte function. We and others have previously delineated a role for the tumor suppressor p53 in adipocyte biology. Here, we show that mice haploinsufficient for MDM2, a key regulator of p53, in thei...
ORGANISM(S): Mus musculus (Mouse) 
2022-02-15 | PXD020812 | Pride
Morc2 Obesity Pparγ C/ebp Mdm2 Lipin1 
UnknownMDM2 facilitates adipocyte differentiation through CRTC-mediated activation of STAT3.
Not available
S-EPMC5108339 | biostudies-literature
UnknownEpidermis-type lipoxygenase 3 regulates adipocyte differentiation and peroxisome proliferator-activated receptor gamma activity.
Not available
S-EPMC2916447 | biostudies-literature
ProteomicsAcute deletion of the glucocorticoid receptor in hepatocytes disrupts postprandial lipid metabolism
Hepatic lipid metabolism is highly dynamic, and disruption of several circadian transcriptional regulators results in hepatic steatosis. This includes genetic disruption of the glucocorticoid receptor (GR) as the liver develops. To address the functional role of GR in the adult liver, we used an acu...
ORGANISM(S): Mus musculus (Mouse) 
2023-09-07 | PXD041168 | Pride
Glucocorticoid receptor knockout mice Dia Mouse Lipid metabolism Circadian rhythm Liver Lc-ms/ms 
UnknownDeep proteome profiling of metabolic dysfunction-associated steatotic liver disease.
Not available
S-EPMC11876662 | biostudies-literature
UnknownPhosphoproteomic profiling reveals a defined genetic program for osteoblastic lineage commitment of human bone marrow-derived stromal stem cells.
Not available
S-EPMC6961576 | biostudies-literature
UnknownThe MDM2-p53-pyruvate carboxylase signalling axis couples mitochondrial metabolism to glucose-stimulated insulin secretion in pancreatic β-cells.
Not available
S-EPMC4897763 | biostudies-literature
UnknownRetinoblastoma protein functions as a molecular switch determining white versus brown adipocyte differentiation.
Not available
S-EPMC384703 | biostudies-literature
UnknownAdipose MDM2 regulates systemic insulin sensitivity.
Not available
S-EPMC8575914 | biostudies-literature
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