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GenomicsIgA Nephropathy GWAS (IGANGWAS)

We report a genome-wide association study of IgA nephropathy, a main cause of kidney failure. All subjects were of Chinese Han ancestry, of which 1,194 were cases and 902 controls. Genomic DNA samples extracted from whole blood were genotyped on the Illumina 610 Quad platform.

phs000431.v1.p1 | EGA
UnknownOptimizing nutrition and metabolism in a severely burned patient during prolonged continuous renal replacement therapy: a case report.
Not available
S-EPMC12849766 | biostudies-literature
UnknownTincr protects against cognitive decline by upregulating MYPT1 mediated phosphorylation of structural protein NM IIA in microglia.
Not available
S-EPMC12755030 | biostudies-literature
TranscriptomicsTwo Histone/Protein Acetyltransferases, CBP and p300, Are Indispensable for Foxp3+ T-regulatory Cell Development and Function
T-regulatory (Treg) cells are important to immune homeostasis, and Treg cell deficiency or dysfunction leads to autoimmune disease. An histone/protein acetyltransferase (HAT), p300, was recently found important for Treg function and stability, but further insights into the mechanisms by which p300 o...
ORGANISM(S): Mus musculus 
2014-08-12 | E-GEOD-60318 | biostudies-arrayexpress
TranscriptomicsRegulatory role of SrrAB two-component system in Staphylococcus epidermidis growth and biofilm formation
Biofilm formation is considered the most important factor involved in pathogenicity of Staphylococcus epidermidis.We investigated the role of two-component signal transduction system (TCS) srrAB, which was up-regulated under micro-aerobic condition, in the growth and biofilm formation of S. epidermi...
ORGANISM(S): Staphylococcus epidermidis 
2014-11-21 | E-GEOD-47101 | biostudies-arrayexpress
ProteomicsIntegrated proteomics reveals autophagy degradation landscape in neurons and receptors regulating neuronal activity
Autophagy is a constitutive process of lysosomal degradation required for maintaining the homeostasis of large molecular complexes and organelles in neurons. Here we reported a systemic investigation of neuronal autophagy targets through integrated proteomics and functional analysis. Proteomic profi...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-06-22 | PXD048730 | Pride
Mass spectrometry Neuron Autophagy degradation Integrated proteomics Tandem mass tag Lc-ms/ms 
MetabolomicsUntargeted metabolomics reveals metabolic mechanism of degrading chicken feathers by Acrophialophora levis

Chicken feathers constitute a major waste in poultry processing due to their resistance to degradation. Microbial degradation offers a promising solution for enhancing the utilization of feather waste. However, the metabolic mechanisms underlying microbial feather degradation remain poorly unders...

2025-11-19 | MTBLS13331 | MetaboLights
UnknownMachine learning-based identification of kbhb-affected tumor cell subsets as prognostic and therapeutic targets in breast cancer.
Not available
S-EPMC12802299 | biostudies-literature
ProteomicsGlobal proteome and phosphoproteome characterization of sepsis-induced kidney injury
Sepsis-induced acute kidney injury (S-AKI) is the most common complication in hospitalized and critically ill patients, highlighted by a rapid decline of kidney function occurring a few hours or days after sepsis onset. Systemic inflammation elicited by microbial infections is believed to lead to ki...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
MSV000086126 | MassIVE
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
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