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TNFα is a cytokine with multiple biological effects. It activates cascading signal pathways by binding to receptors on the cell membrane, regulating processes such as cell growth, differentiation, apoptosis, and inflammatory responses. The formation of skeletal muscle primarily relies on processes s...
ORGANISM(S): Mus musculus (Mouse) 
2024-08-09 | PXD046525 | Pride
Viruses are obligate intracellular parasites that exploit the host metabolic machineries to meet their extraordinary biosynthetic demands. Integrative transcriptomic and lipidomic profiling confirmed that Middle East respiratory syndrome coronavirus (MERS-CoV) infection reprograms the host lipid met...
2018-11-26 | MTBLS762 | MetaboLights
Lethal encephalitis caused by rabies virus (RABV) in mammals is known to be associated with the production of several pro-inflammatory cytokines, but the mechanism of such induction remains unclear. In this study, we found that RABV infects astrocytes which is the most abundant glial cell population...
ORGANISM(S): Mus musculus (Mouse) 
2025-12-29 | PXD058558 | Pride
In this study, we found that spermine (Spm) and spermidine (Spd) injection for 6 weeks could prevent 24-month old rats heart dysfunction,improve mitochondrial function and down-regulate apoptosis. Using iTRAQ tools, we identify 75 mitochondrial proteins of statistically significant alteration in agi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD031270 | Pride
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
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