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MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
ProteomicsShotgun analysis of proteins in USP21 knock-out and WT HAP-1 cells
Deubiquitinases (DUBs) play a role in regulating protein degradation which is critical for maintaining protein homeostasis. The purpose of this study was to verify biological consequence of genetic depletion of USP21 in human cells on proteome changes and cellular function. Comparison of proteomic a...
ORGANISM(S): Homo sapiens (Human) 
2024-10-02 | PXD044105 | Pride
Cancer progression Atp Mitochondrial respiration Usp21 
UnknownHair follicle-associated-pluripotent (HAP) stem cells.
Not available
S-EPMC5736337 | biostudies-literature
UnknownOsteogenic Potential of Sheep Mesenchymal Stem Cells Preconditioned with BMP-2 and FGF-2 and Seeded on an nHAP-Coated PCL/HAP/β-TCP Scaffold.
Not available
S-EPMC9659177 | biostudies-literature
ProteomicsCharacterization of HAP-1 METTL9 KO cells
LAbel free quantitation of HAP1 WT and METTL9 KO cells. METTL9 is a recently established human histidine specific methyltransferase.
ORGANISM(S): Homo sapiens (Human) 
2021-04-28 | PXD023075 | Pride
Human Cell Lc-ms/ms 
ProteomicsProteomics characterization of polysomes from HAP-1 WT and ZCCHC4 KO cells
Proteomics characterization of polysomes from HAP-1 WT and ZCCHC4 KO cells
ORGANISM(S): Homo sapiens (Human) 
2019-11-27 | PXD015084 | Pride
Zcchc4 Polysome 
GenomicsEffects of CDK8/19 mediator kinase inhibition by Senexin B in HAP-1 cells treated with or without interferon-gamma
Effects of CDK8/19 mediator kinase inhibition by Senexin B in HAP-1 cells treated with or without interferon-gamma
PRJNA826456 | ENA
UnknownEarly-age-dependent selective decrease of differentiation potential of hair-follicle-associated pluripotent (HAP) stem cells to beating cardiac-muscle cells.
Not available
S-EPMC5053548 | biostudies-literature
UnknownDirect implantation of hair-follicle-associated pluripotent (HAP) stem cells repairs intracerebral hemorrhage and reduces neuroinflammation in mouse model.
Not available
S-EPMC9838830 | biostudies-literature
UnknownImplanted hair-follicle-associated pluripotent (HAP) stem cells encapsulated in polyvinylidene fluoride membrane cylinders promote effective recovery of peripheral nerve injury.
Not available
S-EPMC5638363 | biostudies-literature
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