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ProteomicsLFQ shotgun proteomic analysis of HAP1 NatC KO cells
The impact of NatC subunits NAA30, NAA35 and NAA38 on the human proteome (protein abundance). Analysis of HAP1 WT, NAA30 KO, NAA35 KO and NAA38 KO cells
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD034104 | Pride
Hap1 cells Natc ko Lfq Shotgun Lc-ms/ms 
TranscriptomicsRNA-seq of coding RNA from USP14 knockout human haploid (HAP1) cells
We performed a genome-scale screen for suppressors of interferon stimulated gene (ISG) expression in human haploid cells (HAP1). Ubiquitin specific peptidase 14 (USP14) was a significant hit. In order to validate USP14 as a regulator of ISG expression, we created knockouts of USP14 in HAP1 cells usi...
ORGANISM(S): Homo sapiens 
2017-07-25 | E-MTAB-5865 | biostudies-arrayexpress
TranscriptomicsRNA-seq of coding RNA from DDX6 knockout human haploid (HAP1) cells
We performed a genome-scale screen for suppressors of interferon stimulated gene (ISG) expression in human haploid cells (HAP1). DEAD-box helicase 6 (DDX6) was a significant hit. In order to validate DDX6 as a regulator of ISG expression, we created knockouts of DDX6 in HAP1 cells using CRISPR-Cas9 ...
ORGANISM(S): Homo sapiens 
2017-07-25 | E-MTAB-5867 | biostudies-arrayexpress
MetabolomicsThe efflux pump ABCC1/MRP1 constitutively restricts PROTAC sensitivity in cancer cells
Proteolysis targeting chimeras (PROTACs) are bifunctional molecules that induce selective protein degradation by linking an E3 ubiquitin ligase enzyme to a target protein. This approach allows scope for targeting “undruggable” proteins and several PROTACs have reached the stage of clinical candidate...
2025-07-17 | MTBLS11394 | MetaboLights
ProteomicsProteomic profiling of centrosomes isolated from HAP1 cells
Centrosomes are cytoplasmic membraneless organelles that comprise a pair of centrioles, and a pericentriolar material. We developed a new centrosome affinity capture method termed CAPture that achieves high-coverage proteomes from 20-30 million cells. Here we present CAPture-MS data from HAP1 cells ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-17 | PXD043692 | Pride
Centrosome Human Hap1 
ProteomicsLC-MSMS analysis of immunoprecipitated JunB-FLAG from HAP1 ADO KO cells
Define the N-terminal acetylation status of human JunB in siCTRL, siNAA10 or siNAA20 treated HAP1 ADO KO cells.
ORGANISM(S): Homo sapiens (Human) 
2024-07-03 | PXD045695 | Pride
Lc-msms Human Junb 
ProteomicsUBR4 KO analysis with TMT labeling
The impact of NatC and UBR4 on the human proteome (protein abundance). Analysis of HAP1 WT siCtr, HAP1 WT siUBR4, HAP1 NAA30 KO siCtr, and HAP1 NAA30 KO siUBR4 cells.
ORGANISM(S): Homo sapiens (Human) 
2023-09-20 | PXD034410 | Pride
Hap1 ko cells Tmt Ubr4 Lc-ms/ms 
GenomicsTranscriptomic analysis of HAP1 DEGS1 KO cells and their wildtype counterpart
Transcriptomic analysis of HAP1 DEGS1 KO cells and their wildtype counterpart
PRJNA880338 | ENA
GenomicsRNA sequencing of HAP1 WT and MED13 KO clones
RNA sequencing of HAP1 WT and MED13 KO clones
PRJNA614013 | ENA
GenomicsGlobal transcriptome analysis of HAP1 cells
Global transcriptome analysis of HAP1 cells
PRJNA436386 | ENA
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