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ProteomicsThree types of Leishmania mexicana amastigotes: proteome comparison by quantitative proteomic analysis
Leishmania is the unicellular parasite transmitted by phlebotomine sand fly bite. It exists in two different forms; extracellular promastigotes, occurring in the gut of sand flies, and intracellular, round-shaped amastigotes residing mainly in vertebrate macrophages. As amastigotes originating from ...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD036664 | Pride
Amastigotes L. mexicana 
ProteomicsIncomplete cytosolic iron-sulfur cluster assembly machinery of Giardia intestinalis is partially associated with mitosomes
Iron - sul fur (Fe -S) clusters are essential cofactors that enable proteins to transport electrons , sense signals or catalyze chemical reactions . The maturation of dozens of Fe - S proteins in various compartments of every eukaryotic cell is driven by several assembly pathways. The ubiquitous cyt...
ORGANISM(S): Giardia intestinalis assemblage A 
2016-09-29 | PXD004722 | Pride
Lc ms Giardi intestinalis 
ProteomicsEvolution Anaerobic peroxisome in Mastigamoeba balamuthi
Adaptation of eukaryotic cells to anaerobic condition is reflected by deep changes in mitochondrial metabolism and their functional reduction. The most modified types of mitochondria are hydrogenosomes that generate molecular hydrogen with concomitant ATP synthesis and mitosome that completely lost ...
ORGANISM(S): Mastigamoeba balamuthi ATTC 30984 
2020-03-04 | PXD014205 | Pride
Mastigamoeba balamuthi Peroxisome Anaerobiosis 
ProteomicsReduced mitochondria provide an essential function for the cytosolic methionine cycle
Since the discovery of eukaryotes without mitochondria, intestinal flagellates oxymonads, it was clear that the loss of mitochondria was facilitated by the remodelling of the FeS cluster synthesis. Yet, this remodelling is common for a broader linage including free-living species with reduced mitoch...
ORGANISM(S): Paratrimastix pyriformis 
2023-03-11 | PXD033021 | Pride
Reduced mitochondria Glycine cleavage system Paratrimastix Mitochondrial loss Lopit One-carbon metabolism Proteome Methionine cycle 
ProteomicsNew derivatives of benzhydroxamic acid with nematocidal activity target nematode specific C2-domain containing protein A0A6F7Q0A8
Parasitic nematodes cause a wide range of diseases in animals, including humans. However, the efficacy of existing anthelmintic drugs, commonly used to treat these infections, is waning due to the increasing prevalence of drug resistance in nematode populations. This growing challenge underscores th...
ORGANISM(S): Haemonchus contortus (Barber pole worm) 
2025-06-16 | PXD059717 | Pride
Nematode H. contortus 
ProteomicsComposition of raft-like cell membrane microdomains resistant to styrene-maleic acid copolymer (SMA) solubilization
An advantageous alternative to the use of detergents in biochemical studies on membrane proteins have recently been styrene-maleic acid (SMA) amphipathic copolymers. These cut the membrane into nanodiscs (often called SMA-lipid particles, SMALPs), which contain membrane proteins surrounded by their ...
ORGANISM(S): Homo sapiens (Human) 
2023-07-26 | PXD031828 | Pride
Sma Lipid rafts 
ProteomicsProteomic analysis of Trichomonas vaginalis phagolysosome, lysosomal targeting, and unconventional secretion of cysteine peptidases
Lysosomes represent a central degradative compartment of eukaryotes, yet little is known about biogenesis and function of this organelle in parasitic protists. Whereas the mannose-6 phosphate (M6P)-dependent system is dominant for lysosomal targeting in metazoans, oligosaccharide independent sorting...
ORGANISM(S): Trichomonas vaginalis 
2023-07-26 | PXD027545 | Pride
Trichomonas vaginalis Glycosylation Mannose-6-phosphate receptor Phagolysosome Cysteine peptidase Proteome 
ProteomicsProteomic analysis of Trichomonas vaginalis phagolysosomes, lysosomal targeting, and unconventional secretion of cysteine peptidases
Lysosome represent a central degradative compartment of eukaryote cells, yet little is known about the biogenesis and function of this organelle in parasitic protists. Whereas the mannose-6 phosphate (M6P)-dependent system is dominant for lysosomal targeting in metazoans, oligosaccharide-independent...
ORGANISM(S): Trichomonas vaginalis 
2021-10-29 | PXD029152 | Pride
Trichomonas vaginalis Glycosylation Mannose-6-phosphate receptor Phagolysosome Cysteine peptidase Proteome 
ProteomicsDynamic T. vaginalis secretome and secretion of β-amalyses
During infection of the urogenital tract, the parasite Trichomonas vaginalis is challenged by factors such as nutrient limitation, the host immune response and coexistence with other members of the microbial fauna. Thus establishment of trichomonad infection depends on multifactorial host-parasite i...
ORGANISM(S): Trichomonas vaginalis 
2017-12-19 | PXD007034 | Pride
Trichomonas vaginalis Secretome 
ProteomicsProteomic profiling of HT1080 fibrosarcoma cells of mesenchymal or amoeboid migratory phenotype
Amoeboid and mesenchymal migration of cancer cells both contribute to metastatic spreading of tumors. To characterize proteome changes underlying the different migratory modes, we performed mass spectrometry profiling of HT1080 fibrosarcoma cells undergoing mesenchymal-amoeboid transition induced by...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD010425 | Pride
Amoeboid Human Cell migration Fibrosarcoma 
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