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MetabolomicsDNA nanomachines reveal an adaptive energy mode in confinement-induced amoeboid migration powered by polarized mitochondrial distribution

Energy metabolism is highly interdependent with adaptive cell migration in vivo. Mechanical confinement is a critical physical cue that induces switchable migration modes of the mesenchymal-to-amoeboid transition (MAT). However, the energy states in distinct migration modes, especially a...

2024-03-25 | MTBLS9657 | MetaboLights
TranscriptomicsTranscriptomic profiling of HT1080 fibrosarcoma cells of mesenchymal or amoeboid migratory phenotype
Amoeboid and mesenchymal migration of cancer cells both contribute to metastatic spreading of tumors. To characterize gene expression profiles underlying the different migratory modes, we performed RNA sequencing of HT1080 fibrosarcoma cells undergoing mesenchymal-amoeboid transition induced by eith...
ORGANISM(S): Homo sapiens 
2019-07-29 | E-MTAB-6823 | biostudies-arrayexpress
ProteomicsProteomic profiling of HT1080 fibrosarcoma cells of mesenchymal or amoeboid migratory phenotype
Amoeboid and mesenchymal migration of cancer cells both contribute to metastatic spreading of tumors. To characterize proteome changes underlying the different migratory modes, we performed mass spectrometry profiling of HT1080 fibrosarcoma cells undergoing mesenchymal-amoeboid transition induced by...
ORGANISM(S): Homo sapiens (Human) 
2020-04-23 | PXD010425 | Pride
Amoeboid Human Cell migration Fibrosarcoma 
TranscriptomicsExpression data from amoeboid and ramified microglia isolated from the corpus callosum of 5-day and 4-week old rat brain
Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC) alongside several intermediate forms. The AMC are ...
ORGANISM(S): Rattus norvegicus 
2011-06-11 | E-GEOD-29885 | biostudies-arrayexpress
ProteomicsRegulation of microtubules by DIAPH3 loss influences amoeboid tumor cell sensitivity to taxanes
Diaphanous-related formin-3 (DIAPH3), a cytoskeletal regulator of the formin family, is lost at high frequency in metastatic breast and prostate cancers and has characteristics of a non-canonical metastasis suppressor. We previously demonstrated that DIAPH3 silencing evokes transition to an “amoeboi...
ORGANISM(S): Homo sapiens (Human) 
2015-07-27 | PXD001192 | Pride
Taxanes Mass spectrometry Prostate cancer Amoeboid Microtubules Label-free Chemotherapy Formin Metastasis 
TranscriptomicsscRNA-seq and differential expression analyses of metastatic melanoma cells before, during and after tumour escape
Highly invasive integrin and protease-independent amoeboid migration is often employed by cancer cells at the invasive front, though little is known about the transcriptomic changes underlying the switch to an amoeboid migratory mode. Using a metastatic melanoma cell line expressing photoconvertible...
ORGANISM(S): Homo sapiens 
2022-05-21 | E-MTAB-11722 | biostudies-arrayexpress
TranscriptomicsMesenchymal to amoeboid transition is associated with stem-like features of melanoma cells
Cellular plasticity confers cancer cells the ability to adapt to micro-environmental changes, a fundamental requirement for tumour progression and metastasis. The epithelial to mesenchymal transition (EMT) is a transcriptional programme associated with increased cell motility and stemness. Beside EM...
ORGANISM(S): Homo sapiens 
2014-04-22 | E-GEOD-52246 | biostudies-arrayexpress
GenomicsTranscriptomic profiling of HT1080 fibrosarcoma cells of mesenchymal or amoeboid migratory phenotype
Transcriptomic profiling of HT1080 fibrosarcoma cells of mesenchymal or amoeboid migratory phenotype
PRJEB27009 | ENA
ProteomicsRASSF1C oncogene elicits amoeboid invasion, cancer stemness and invasive EVs via a novel SRC/Rho axis
Cell plasticity is a crucial hallmark leading to cancer metastasis. Upregulation of Rho/ROCK pathway drives actomyosin contractility, protrusive forces and contributes to the occurrence of highly invasive amoeboid cells in tumors. Cancer stem cells are similarly associated with metastasis, but how t...
ORGANISM(S): Homo sapiens (Human) 
2021-10-07 | PXD026226 | Pride
Rassf1c Exosome 
GenomicsAmoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity [scRNA-seq]
Amoeboid-Mesenchymal Transition and the Proteolytic Control of Cancer Invasion Plasticity [scRNA-seq]
PRJNA1380334 | ENA
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