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ProteomicsUSP28 enables oncogenic transformation of respiratory cells and its inhibition potentiates molecular therapy targeting mutant EGFR, BRAF and PI3K.
Oncogenic transformation of lung epithelial cells is a multi-step process, frequently starting with the inactivation of tumor suppressors and subsequent activating mutations in proto-oncogenes, such as members of the PI3K or MAPK family. Cells undergoing transformation have to adjust to changes, suc...
ORGANISM(S): Homo sapiens (Human) 
2022-04-08 | PXD032810 | Pride
Braf Buparlisib C-jun Vemurafenib Usp28 Lung cancer Egfr Pik3ca C-myc Hras gefitinib 
UnknownThe non-ELR CXC chemokine encoded by human cytomegalovirus UL146 genotype 5 contains a C-terminal β-hairpin and induces neutrophil migration as a selective CXCR2 agonist.
Not available
S-EPMC8939814 | biostudies-literature
UnknownFungal phytochrome chromophore biosynthesis at mitochondria
Not available
S-SCDT-EMBOJ-2021-108083 | biostudies-other
UnknownADAM10 mediates E-cadherin shedding and regulates epithelial cell-cell adhesion, migration, and beta-catenin translocation.
Not available
S-EPMC1166595 | biostudies-literature
ProteomicsMigraine-associated mutation in the Na,K-ATPase leads to disturbances in cardiac metabolism and reduced cardiac function
Background. Mutations in ATP1A2 gene encoding the Na,K-ATPase α2 isoform is associated with familial hemiplegic migraine type 2 (FHM2). Migraine with aura is a known risk factor for heart disease. The Na,K-ATPase is important for cardiac function but its role for heart disease remains unknown. We hy...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2022-05-20 | PXD028952 | Pride
Heart failure Oxidant stress Gene expression and regulation Cell signaling Contractile function 
UnknownFunctional Characterisation of Alternative Oxidase Protein Isoproteins in Arabidopsis thaliana
Not available
S-EPMC12391748 | biostudies-literature
UnknownRoom-Temperature Solid-State Transformation of Na4 SnS4  ⋅ 14H2 O into Na4 Sn2 S6  ⋅ 5H2 O: An Unusual Epitaxial Reaction Including Bond Formation, Mass Transport, and Ionic Conductivity.
Not available
S-EPMC10099607 | biostudies-literature
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset (RNAi)
The MOF-containing NSL complex binds to many but not all promoters of active genes and potentially contributes to their proper gene expression. It is currently unknown what determines whether an active gene is bound or not. Here, we provide evidence that the NSL complex primarily targets active prom...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30990 | biostudies-arrayexpress
UnknownMalassezia restricta promotes alcohol-induced liver injury.
Not available
S-EPMC9988279 | biostudies-literature
TranscriptomicsThe MOF-containing NSL complex associates globally with housekeeping genes, but activates only a defined subset
This SuperSeries is composed of the following subset Series: GSE30989: MOF-containing NSL complex specifically binds promoters of most, but stimulates only a specific subset of, housekeeping genes (ChIP-chip dataset) GSE30990: MOF-containing NSL complex specifically binds promoters of most, but stim...
ORGANISM(S): Drosophila melanogaster 
2011-10-28 | E-GEOD-30991 | biostudies-arrayexpress
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