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TranscriptomicsNatalizumab exerts direct signaling capacity and supports a pro-inflammatory phenotype in some patients with multiple sclerosis
Natalizumab is a recombinant monoclonal antibody raised against integrin alpha-4 (CD49d). It is approved for the treatment of patients with multiple sclerosis (MS), a chronic inflammatory autoimmune disease of the CNS. Natalizumab blocks leukocyte extravasation across the blood-brain barrier by inhi...
ORGANISM(S): Homo sapiens 
2015-05-02 | E-GEOD-37783 | biostudies-arrayexpress
UnknownAnalysis of transcriptional regulation of the human miR-17-92 cluster; evidence for involvement of Pim-1.
Not available
S-EPMC3709785 | biostudies-literature
UnknownAlkalinity responses to climate warming destabilise the Earth's thermostat.
Not available
S-EPMC10039064 | biostudies-literature
ProteomicsThermococcus kodakarensis proteins expressed at various temperatures reveals changes in RNA modifications
Thermococcus kodakarensis is a thermophilic archaea used in this study to determine how changes in growth temperature affect protein expression. This organism was chosen, in part, due to the simplified proteome and potential protein stability gained when analyzing proteins at room temperature. Two t...
ORGANISM(S): Thermococcus kodakarensis KOD1 
2020-02-17 | PXD014814 | Pride
Proteomics Thermococcus kodakarensis Theromphile Qexactive plus 
ProteomicsDevelopment and qualification of a dendritic cell internalization assay contributing to the immunogenicity risk evaluation of biotherapeutics
The appended raw files, csv files and other documents were deposited into the public domain in support for the publication "Development and characterization of a dendritic cell internalization assay contributing to the immunogenicity risk evaluation of biotherapeutics" by Michel Siegel, Aman Padamse...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-08-12 | MSV000095578 | MassIVE
UnknownLazyB: fast and cheap genome assembly.
Not available
S-EPMC8168326 | biostudies-literature
ProteomicsActive AKT Signaling triggers CLL towards Richter's transformation via over-activation of Notch1
Richter's syndrome (RS) is an aggressive transformation of Chronic Lymphocytic Leukaemia (CLL) frequently due to TP53, CDKN2, MYC or NOTCH1 mutations. whereas a significant proportion displays no specifically acquired driver mutation. We observe constitutive AKT phosphorylation not only in high-risk...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-25 | PXD017457 | Pride
S100 Notch1 Akt Cll Richter syndrome 
UnknownTic-Talk: Voices on Tourette's Labelling.
Not available
S-EPMC12274994 | biostudies-literature
ProteomicsQuantitative proteomics of immunocaptured mitochondria from Astrocytes
Mitochondria vary in morphology and function in different tissues, however little is known about their molecular diversity among cell types. To investigate mitochondrial diversity in vivo, we developed an efficient protocol to isolate cell type-specific mitochondria based on a new MitoTag mouse. We ...
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD010781 | Pride
Astrocytes Mitochondria 
ProteomicsCerebellum Proteomics - Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity
A whole cerebellum proteome analysis was performed to compare the data to cell specific mitochondria proteomics in the same brain region.
ORGANISM(S): Mus musculus (Mouse) 
2019-09-03 | PXD013380 | Pride
Cerebellum Brain Mouse 
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