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ProteomicsCdc42 phosphorylation study - Cdc42 Regulates Neuronal Polarity during Cerebellar Axon Formation and Glial-Guided Migration
Govek et al. demonstrate conditional loss of Cdc42 in cerebellar granule cell progenitors (GCPs) perturbs GCP polarity and impairs axon patterning, glial-guided migration, and cerebellar foliation. Phospho-proteomic analysis identified polarity and cytoskeletal proteins as affected targets in Cdc42 ...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-22 | PXD008148 | Pride
Brain Mouse Phospho 
ProteomicsMice lacking Astn2 have ASD-like behaviors and altered cerebellar circuit properties
Astrotactin 2 (ASTN2) is a transmembrane neuronal protein highly expressed in the cerebellum that functions in receptor trafficking and modulates cerebellar Purkinje cell (PC) synaptic activity. Individuals with ASTN2 mutations exhibit neurodevelopmental disorders, including autism spectrum disorder...
ORGANISM(S): Mus musculus (Mouse) 
2024-07-30 | PXD052868 | Pride
Astn2 Purkinje cell Neurodevelopmental disorder Cerebellum Autism spectrum disorder 
TranscriptomicsRole of Tet1/3 Genes and Chromatin Remodeling Genes in Cerebellar Circuit Formation
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-74402 | biostudies-arrayexpress
GenomicsRole of Tet1 and Tet3 genes and Chromatin Remodeling in Cerebellar Circuit Formation [hMe-Seal]
Although mechanisms underlying early steps in cerebellar development are known, evidence is lacking on genetic and epigenetic changes during the establishment of the synaptic circuitry. Using metagene analysis, we report pivotal changes in multiple reactomes of epigenetic pathway genes in cerebellar...
ORGANISM(S): Mus musculus 
2015-10-31 | E-GEOD-74401 | biostudies-arrayexpress
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