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ProteomicsNeuroretinal-derived caveolin-1 promotes endotoxin-induced inflammation in the murine retina
Chronic ocular inflammation is associated with many retinal degenerative diseases that result in vision loss. The immune-privileged environment and complex organization of retinal tissue allow for the retina’s essential role in visual function processes, yet confound inquiries into cell-specific inf...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-08 | PXD016872 | Pride
Caveolin-1  caveolin  caveolae  inflammation  neural retina  retina  retinal degeneration  immune response 
ProteomicsProteome changes in retinal Mueller glial cells from a spontaneous equine model for autoimmune uveitis compared to healthy controls
Retinal Müller glial cells (RMG) play a central role in retinal neuroinflammation, actively participating in the immune response and adopting a dynamic inflammatory phenotype. However, the precise functions of RMG in retinal inflammation remain incompletely understood. In this study, we investigated...
ORGANISM(S): Equus caballus (Horse) 
2025-05-07 | PXD058170 | Pride
Quantitative label-free lc-ms/ms  retinal neuroinflammation  autoimmune uveitis  equine recurrent uveitis (eru)  spontaneous equine animal model  retinal mueller glial cells (rmg) 
ProteomicsAltered porcine PBMC proteome and secretome after stimulation with BanLec
With this experiment, we aimed at showing changes in the proteome and secretome of porcine peripheral blood mononuclear cells (PBMC) after stimulation with Banana Lectin (BanLec).
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-08-26 | PXD027505 | Pride
Pbmc Musa banana Polyclonal cell stimulation Banlec Plant lectin Pig Lc-ms/ms 
ProteomicsChanges in Mycobacterium avium subsp. paratuberculosis proteome after cultivation in milk
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease in cattle. MAP can be either shed directly into milk by infected cows, or introduced via fecal contamination. Viable MAP are detectable in milk and other dairy products, indicating survival of MAP after t...
ORGANISM(S): Bos taurus (Bovine) Mycobacterium avium subsp. paratuberculosis 
2021-08-26 | PXD027444 | Pride
Mycobacterium avium subspecies paratuberculosis Dairy product Milk Food safety Lc-ms/ms 
ProteomicsThe injury environment critically influences the brain-wide input connectome of transplanted neurons
Cell transplantation is a promising approach for reconstruction of neuronal circuits after brain damage. Transplanted neurons integrate with remarkable specificity into circuitries of the mouse cerebral cortex affected by neuronal ablation. However, it remains unclear how neurons perform in a local ...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD023660 | Pride
Neuronal replacement Circuit mapping Cell therapy Inflammation Transplantation Synaptic yield Injury proteome 
ProteomicsExcessive local host-graft connectivity in aged and amyloid-loaded brain
Transplantation is a clinically relevant approach for brain repair, but much remains to be understood about influences of the disease environment in the host on transplant connectivity. To explore the influence of ageing and amyloid pathology in Alzheimer's disease (AD) we examined graft connectivit...
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD023407 | Pride
Synaptic connectivity Mouse brain Alzheimer's disease model Aging 
ProteomicsVitreous proteome of transgenic INSC94Y pigs compared to wild type
INSC94Y transgenic pigs serve as a valuable model for permanent neonatal diabetes mellitus. Through genetically engineered modifications in the insulin (INS) gene, this model presents with impaired insulin secretion, resulting elevated fasting blood-glucose levels (hyperglycemia) [1].One of the seve...
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2024-08-27 | PXD038198 | Pride
Quantitative label-free lc-ms/ms  diabetes mellitus  permanent neonatal diabetes  diabetic retinopathy  genetically modified pig  insc94y  porcine model  vitreous 
ProteomicsA lysine residue at the C-terminus of MHC class I ligands correlates with low C-terminal proteasomal cleavage probability
The majority of peptides presented by MHC class I results from proteasomal protein turnover. The specialized immunoproteasome, which is induced during inflammation, plays a major role in antigenic peptide generation. However, other cellular proteases can, either alone or together with the proteasome...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD044235 | Pride
Immunopeptidomics  proteasome-independent  non-canonical mhc class i ligands  hla-a*03:01  hla-a*11:01  hla-a*30:01  proteasomal cleavage probability  peptide origin  peptide processing 
ProteomicsMycobacterium avium subsp. paratuberculosis infected cows reveal divergent immune response in bovine peripheral blood derived lymphocyte proteome
Bovine paratuberculosis is a serious chronic disease of the gastrointestinal tract caused by Mycobacterium avium subspecies paratuberculosis (MAP). The aim of this study was to detect proteomic changes in peripheral blood mononuclear cells (PBMC) from cows of the same herd with different MAP infecti...
ORGANISM(S): Bos taurus (Bovine) 
2023-03-10 | PXD036881 | Pride
Paratuberculosis  mycobacteria  host-pathogen response  immune system  quantitative label-free lc-ms/ms  bovine 
ProteomicsPantothenate kinase 4 controls skeletal muscle substrate metabolism
Metabolic flexibility in skeletal muscle is essential for maintaining healthy glucose and lipid metabolism, and its dysfunction is closely linked to metabolic diseases. Exercise enhances metabolic flexibility, making it an important tool for discovering mechanisms that promote efficient energy metab...
ORGANISM(S): Mus musculus (Mouse) 
2024-10-25 | PXD057017 | Pride
Pantothenate kinase 4 (pank4) Lipid and glucose metabolism Skeletal muscle 
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