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MetabolomicsMetabolomic changes in Mycobacterium avium subsp. paratuberculosis (MAP) challenged Holstein-Friesian cattle suggest the role of serum amino acids as indicators of immune system activation

INTRODUCTION: Paratuberculosis, commonly known as Johne’s disease, is a chronic intestinal infection of ruminants caused by Mycobacterium avium subspecies paratuberculosis (MAP). Clinical signs, including reduced milk yields, weight loss and diarrhoea, are typically abse...

2022-02-23 | MTBLS2963 | MetaboLights
TranscriptomicsMycobacterium avium subsp. paratuberculosis gene transcription in simulated phagosomal environment and in human macrophage infection
This SuperSeries is composed of the following subset Series: GSE32241: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro acid-nitrosative multi-stress GSE32242: Differentially regulated genes induced in Mycobacterium avium subspecies paratuberculos...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32243 | biostudies-arrayexpress
ProteomicsIdentification of immunoreactive proteins of Mycobacterium avium subsp. Paratuberculosis
Mycobacterium avium subsp. paratuberculosis (MAP) is the cause of a chronic enteritis of ruminants (bovine paratuberculosis-Johne disease) that is associated with enormous worldwide economic losses for the zootechnical industries. Diagnosis is based on observation of clinical signs, on the detection...
ORGANISM(S): Mycobacterium paratuberculosis (strain ATCC BAA-968 / K-10) Other Actinobacteria (class) 
2014-11-20 | PXD001159 | Pride
Mycobacterium avium subsp. paratuberculosis  johne’s disease  immunoreactive proteins  soil biological contaminant 
TranscriptomicsThe Intracellular Life of Mycobacterium avium subsp. paratuberculosis During Macrophage Stress: A Key Role for the Alternative Sigma Factor, SigH
Mycobacterium avium subspecies paratuberculosis (a.k.a. M. paratuberculosis) causes JohneM-bM-^@M-^Ys disease, an enteric infection in cattle and other ruminants, greatly afflicting the dairy industry worldwide. Once inside the cell, M. paratuberculosis is known to survive harsh microenvironments, ...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis K-10 
2012-12-29 | E-GEOD-43182 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of whole-blood in Mycobacterium avium subsp. paratuberculosis-infected cattle
To provide novel insights into understanding the host-immune response during the different stages of progression of the disease, we performed gene expression profiling in Mycobacterium avium subsp. paratuberculosis infection in cattle. We analyzed the transcriptional profiles of whole-blood cells of...
ORGANISM(S): Bos taurus 
2014-10-31 | E-GEOD-62835 | biostudies-arrayexpress
ProteomicsChanges in Mycobacterium avium subsp. paratuberculosis proteome after cultivation in milk
Mycobacterium avium subspecies paratuberculosis (MAP) is the causative agent of Johne’s disease in cattle. MAP can be either shed directly into milk by infected cows, or introduced via fecal contamination. Viable MAP are detectable in milk and other dairy products, indicating survival of MAP after t...
ORGANISM(S): Bos taurus (Bovine) Mycobacterium avium subsp. paratuberculosis 
2021-08-26 | PXD027444 | Pride
Mycobacterium avium subspecies paratuberculosis Dairy product Milk Food safety Lc-ms/ms 
TranscriptomicsRNA-seq of the ileo-caecal valve lymph node of sheep with paratuberculosis compared to uninfected controls
Sheep total RNA was extracted from the Ileo-caecal valve lymph node (ICLN) of sheep with multibacillary paratuberculosis compared to ICLN of uninfected controls. Sequencing libaries were prepared from RNA using the Illumina TruSeq RNA Sample Preparation Kit v2. Sequencing with 101 base paired end re...
ORGANISM(S): Ovis aries 
2017-05-03 | E-MTAB-5146 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of Mycobacterium avium subsp. paratuberculosis cattle and sheep strains grown under in vitro iron limiting or iron sufficient conditions
Transcriptional responses of two strain types of Mycobacterium avium subsp. paratuberculosis (MAP, cattle and sheep Strain) under in vitro iron limiting or iron sufficient growth conditions. Background: In MAP, the transcriptional role and essentiality of MAP2827 (IdeR) as an iron dependent regulato...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2010-10-31 | E-MEXP-2865 | biostudies-arrayexpress
TranscriptomicsBovine Peyer's Patch Infected with Mycobacterium avium ssp. paratuberculosis and Mycobacterium avium ssp. avium
Mycobacterium avium subspecies paratuberculosis (MAP) infection is established following the ingestion of bacteria, their penetration of the intestinal mucosa and subsequent events of the host-parasite interaction. These bacteria invade M cells, macrophages and are capable of resisting host defenses...
ORGANISM(S): Bos taurus 
2012-10-03 | E-GEOD-13888 | biostudies-arrayexpress
TranscriptomicsDifferentially regulated genes induced in Mycobacterium avium subspecies paratuberculosis by in vitro acid-nitrosative multi-stress
Transcriptional profile of Mycobacterium avium subspecies paratuberculosis in in vitro acid-nitrosative multistress, comparing untreated control cells and bacteria under multi-stress. Two-condition experiment, MAP-K vs. MAP-ACID-NO treated. Biological replicates: 3 controls, 3 Acid-NO treated, indep...
ORGANISM(S): Mycobacterium avium subsp. paratuberculosis 
2012-05-31 | E-GEOD-32241 | biostudies-arrayexpress
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