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TranscriptomicsT cell acute leukaemia development and chemo-resistance are mediated by dynamic interactions with heterogeneous bone marrow microenvironments.
It is widely accepted that complex interactions between cancer cells and their surrounding microenvironment contribute to disease development, chemo-resistance and disease relapse. In light of this observed interdependency, novel therapeutic interventions that target specific cancer stroma cell line...
ORGANISM(S): Homo sapiens 
2016-07-01 | E-MTAB-4889 | biostudies-arrayexpress
MetabolomicsA multi-omics approach to unravel the interaction between heat and drought stress in the Arabidopsis thaliana holobiont
The impact of combined heat and drought stress was investigated in Arabidopsis thaliana and compared to individual stresses to reveal additive effects and interactions. A combination of plant metabolomics and root and rhizosphere bacterial metabarcoding were used to unravel effects at the plant holo...
2024-12-16 | MTBLS7365 | MetaboLights
ProteomicsThe PI3Kδ interactome in naïve and activated mouse CD4+ T cells
Phosphoinositide 3-kinases (PI3Ks) play a central role in adaptive immunity by transducing signals from the T cell antigen receptor (TCR) via production of PIP3. PI3Kδ is a heterodimer composed of a p110δ catalytic subunit associated with a p85α or p85β regulatory subunit and is preferentially engag...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-08 | PXD022607 | Pride
Ap-ms 10-plex Pi3k Tmt T-cells Pi3kδ Nlc-ms/ms Cd4+ Mouse Tcr Interactome 
GenomicsGenome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells
STAT6 is a major transcription factor driving the polarization of Th2 cells in response to IL-4. STAT6 is phosphorylated by Jak1 and Jak3 kinases at the IL-4 receptor, after which phosphorylated STAT6 forms a homodimer and translocates into the nucleus. There STAT6 binds to specific DNA sequences, r...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-17850 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of early transcriptional events induced by cytokine IL-4 in human cord blood CD4+ T cells
The aim of this dataset was to study in detail the transcription kinetics initiated by cytokine IL-4 in early differentiation of Th2 cells. Total RNA obtained from activated and IL-4 & anti-IL-12 treated cord blood CD4+ T cells, 0.5, 1, 2, 4, 6, 12, 24, 48, and 72 hours after initiation of the cultu...
ORGANISM(S): Homo sapiens 
2010-06-25 | E-GEOD-17974 | biostudies-arrayexpress
TranscriptomicsIdentification of global regulators of T-helper cell lineage specification (BeadChip)
The aim of the dataset was to identify genome-wide regulators of gene expression in early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) and Th2 (Act+IL4) polarising conditions. Total RNA from naive CD4+ T cells was compared to total RNA from cells cultured in...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-71575 | biostudies-arrayexpress
TranscriptomicsIdentification of global regulators of T-helper cell lineage specification (RNA-Seq)
The aim of the dataset was to identify genome-wide regulators of gene expression in early differentiation of human cord blood derived CD4+ T cells cultured under Th1 (Act+IL12) and Th2 (Act+IL4) polarizing conditions. Total RNA from naive CD4+ T cells was compared to total RNA from cells cultured in...
ORGANISM(S): Homo sapiens 
2015-11-20 | E-GEOD-71645 | biostudies-arrayexpress
TranscriptomicsStat6 mediated regulation of transcription to initiate Th2 program in human T cells
This SuperSeries is composed of the following subset Series: GSE17850: Genome-wide detection of STAT6 binding sites in IL-4 treated naive human CD4+ T cells GSE17851: Genome-wide analysis of STAT6 target genes in IL-4 treated human cord blood CD4+ cells GSE17974: Genome-wide analysis of early transc...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-18017 | biostudies-arrayexpress
ProteomicsIn-depth analysis of the phosphoprotein landscape of cytotoxic T lymphocytes and its regulation by cytokines
Here we present high-resolution mass spectrometry analysis of changes to the phosphoproteome of cytotoxic T lymphocytes (CTL) induced by the cytokine, Interleukin 12 (IL-12). We treated CTL with a short and long IL-12 stimulation and mapped the changes to the phosphoproteome using quantitative SILAC...
ORGANISM(S): Mus musculus (Mouse) 
2016-08-24 | PXD004644 | Pride
Silac Il-12 Phosphoproteomics Lymphocytes 
GenomicsA validated gene regulatory network and GWAS identifies early regulators of T-cell associated diseases (ChIP-Seq)
For the purpose of the Gene Regulatory Network validation we have performed chromatin-immunoprecipitation sequencing (ChIP-Seq) experiment for three transcription factors; namely GATA3, MAF and MYB. ChIP-Seq of GATA3, MAF and MYB in human naïve CD4+ T-cells differentiated toward Th1 and Th2 until d...
ORGANISM(S): Homo sapiens 
2015-11-12 | E-GEOD-72266 | biostudies-arrayexpress
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