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ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080778 | MassIVE
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells, part 2
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-31 | MSV000080852 | MassIVE
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells, part 2
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo sapiens (Human) 
2016-12-24 | PXD004995 | Pride
Lysine acetylation Aspirin Hela 
ProteomicsSites of aspirin-mediated lysine acetylation in HeLa cells
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. Important to this function is its ability to irreversibly acetylate cyclooxygenases at active site serines. Aspirin has the potential to acetylate other amino-acid side-chains, leading to speculation that aspiri...
ORGANISM(S): Homo sapiens (Human) 
2017-01-10 | PXD003530 | Pride
Lysine acetylation Aspirin Hela 
ProteomicsIdentification of SUMO targets required to maintain human stem cells in the pluripotent state. - Characterisation of 6His-SUMO-KGG-mCherry ChiPS4 cells
To determine the role of SUMO modification in the maintenance of pluripotent stem cells we used ML792, a potent and selective inhibitor of SUMO Activating Enzyme. Treatment of human induced pluripotent stem cells with ML792 initiated changes associated with loss of pluripotency such as reduced expre...
ORGANISM(S): Homo sapiens (Human) 
2021-11-03 | PXD023241 | Pride
Sumo Stem cells Ml792 
ProteomicsHalf-lives of aspirin-mediated lysine acetylations
Aspirin, or acetylsalicylic acid is widely used to control pain, inflammation and fever. An important property of aspirin is its ability to acetylate multiple cellular proteins with some pharmacological functions explicable by the irreversible acetylation of cyclooxygenases at active site serine res...
ORGANISM(S): Homo sapiens (Human) 
2019-03-05 | PXD003655 | Pride
Aspirin Acetylation Lysine 
ProteomicsChanges to SUMO2 conjugation during Influenza virus infection of cultured cells
Dynamic SUMO modifications of diverse cellular protein groups are critical to orchestrate resolution of stresses such as genome damage, hypoxia or proteotoxicity. Defense against pathogen insult (usually reliant upon host recognition of ‘non-self’ nucleic acids), is also modulated by SUMO, but the u...
ORGANISM(S): Homo sapiens (Human) 
2019-08-12 | PXD014136 | Pride
Ns1 Influenza Sumo 
ProteomicsMitochondrial proteome from liver and intestinal organoids from WT, Nrf2 knockout and Keap1 knockdown mice
Transcription factor nuclear factor erythroid 2 p45-related factor 2 (Nrf2) and its main negative regulator, Kelch-like ECH associated protein 1 (Keap1), are at the interface between redox and intermediary metabolism, allowing adaptation and survival under conditions of oxidative, inflammatory and m...
ORGANISM(S): Mus musculus (Mouse) 
2020-11-11 | PXD021639 | Pride
Organoids Mitochondrial Keap1 Nrf2 Liver Mouse 
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