Hdx-ms mapping - OmicsDI

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Chemical Proteomics, Division of Chemistry I, Department of Medical Biochemistry and Biophysics Karolinska Institutet, Stockholm, Sweden (1)
Laboratory of Structural Biology and Cell Signaling, Institute of Microbiology, The Czech Academy of Sciences, Prague, 14220, Czech Republic (1)
Division of Infection Medicine, Department of Clinical Sciences, Faculty of Medicine, Lund University, Klinikgatan 26, 222 42 Lund, Sweden (1)
RECAMO, Masaryk Memorial Cancer Institute Zluty Kopec, Brno, Czech Republic (1)
Living Systems Institute, University of Exeter, EX4 4QD, UK (1)
Roivant sciences, Discovery Platform, Advanced simulations, New York City, NY (1)
VP, Advanced Simulations, Roivant Discovery, Inc (1)
Institute of Physics, Polish Academy of Sciences, Warsaw, Poland (1)

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Epitope Mapping of Human Polyclonal Antibodies to the fHbp Antigen of a Neisseria Meningitidis Vaccine by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS) - part 2

Antigen-antibody interactions play a key role in the immune response post vaccination and the mechanism of action of antibody-based biopharmaceuticals. 4CMenB is a multicomponent vaccine against Neisseria meningitidis serogroup B in which factor H binding protein (fHbp) is one of the key antigens. I...

ORGANISM(S): Homo sapiens (Human)

2024-05-22 | PXD047712 | Pride

Epitope Mapping of Human Polyclonal Antibodies to the fHbp Antigen of a Neisseria Meningitidis Vaccine by Hydrogen-Deuterium Exchange Mass Spectrometry (HDX-MS)

ORGANISM(S): Homo sapiens (Human)

2024-05-24 | PXD046572 | Pride

Polyclonal antibodies Pab Fhbp Hdx-ms

HDX-MS of Immobilized Staph Enterotoxin B with Neutralizing Serum

Elucidating the interactions that drive antigen recognition is central to understanding antibody-based protection and is vital for the rational design of immunogens. Often, structural knowledge of epitopes targeted by antibodies is derived from isolated studies of monoclonal antibodies, for which nu...

ORGANISM(S): Mus musculus (Mouse)

2025-10-27 | PXD051156 | Pride

Hdx-ms Serum hdx Seb Immobilized hdx

Epitope mapping of diverse influenza Hemagglutinin drug candidates using HDX-MS.

Not available

S-EPMC6427009 | biostudies-literature

Identification of the epitope recognized by a specific VHH raised against the Th17 antigen (AID45212)

Segmented filamentous bacteria (SFB) are ubiquitous intestinal commensals that promote immune system development and pathogen protection. The unicellular teardrop-shaped SFB, called intracellular offsprings (IOs), attach to ileal epithelial cells via their unique tip structure and outgrow into filam...

ORGANISM(S): Escherichia coli

2025-10-21 | PXD060041 | Pride

Segmented filamenteous bacteria (sfb) Hydrogen/deuterium exchange mass spectrometry (hdx-ms) Epitope mapping Th17 antigen (aid45212)

RSV nonstructural protein 1 (NS1) HDX LC-MS data

Raw liquid chromatography-mass spectrometry (LC-MS) datafiles acquired for hydrogen-deuterium exchange (HDX) of RSV nonstructural protein 1 (NS1)

ORGANISM(S): Human Respiratory syncytial virus 9320

2025-05-07 | PXD054005 | Pride

Rsv ns1 hdx-ms

Bottom-up mapping of RSV nonstructural protein 1 (NS1) for HDX-MS data analysis

LC-MS/MS analysis of pepsin-digested RSV-NS1 protein to identify peptides for HDX-MS data processing

ORGANISM(S): Respiratory syncytial virus

2025-05-07 | PXD054004 | Pride