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ProteomicsIntracellular proteins adsorbed on AuNPs during transcytosis and exocytosis
we set protein corona as the research object in this study, and focused on exploring the biological effects of intracellular protein corona (IPC) that formed on particle surface after transcytosis of nanomedicines. Considering the multi-functionalization characteristic, gold nanoparticles (AuNPs) we...
ORGANISM(S): Homo sapiens (Human) 
2020-01-20 | PXD015651 | Pride
Transcytosis Exocytosis Protein corona Caco-2 Aunps 
ProteomicsThe proteomic navigator of human aging
Proteins are the cornerstone of human life, yet the proteomic landscape of aging across human tissues remains largely unexplored. Here, we present a comprehensive proteomic analysis of 520 samples from 15 human tissues, spanning a 50-year lifespan. Our study compiles a proteomic encyclopedia of mult...
ORGANISM(S): Homo Sapiens 
2024-12-06 | PXD058638 |
ProteomicsARIH1 Signaling Promotes Anti-tumor Immunity by Targeting PD-L1 for Proteasomal Degradation
We find EGFR inhibitors promote PD-L1 ubiquitination and proteasomal degradation following GSK3α-mediated phosphorylation of Ser279/Ser283.
ORGANISM(S): Homo Sapiens 
2021-03-01 | PXD024452 |
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