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MetabolomicsGut microbiota derived metabolite protects against heart failure with preserved ejection fraction

Targeted metabolomics analysis was performed to examine the differences in metabolite in fecal samples of heart failure with preserved ejection fraction (HFpEF) and control mice.

2024-11-29 | MTBLS10336 | MetaboLights
MetabolomicsPyruvate metabolism enzyme Dlat induces mitochondria protein hyperacetylation to limit fatty acid oxidation in the HFpEF heart

Increased protein acetylation is frequently observed in the failing heart, including in hearts with heart failure with preserved ejection fraction (HFpEF). However, the role of protein acetylation in cardiac metabolic impairments during the pathogenesis of HFpEF remains insufficiently investigate...

2025-09-01 | MTBLS12919 | MetaboLights
ProteomicsSystemic Pathogenesis of Different Phenotypes of Heart Failure with Preserved Ejection Fraction.
Heart failure with preserved ejection fraction (HFpEF) accounts for ~50% of all heart failure cases. HFpEF is a heterogeneous condition with poorly understood molecular mechanisms related to different forms including acute and chronic HFpEF. Here, we utilised plasma samples collected from patients w...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD024012 | Pride
Biomarkers Heart failure with preserved ejection fraction Plasma Hypertrophic cardiomyopathy Lc-ms/ms 
ProteomicsUnveiling human proteome signatures of heart failure with preserved ejection
Heart Failure with preserved ejection fraction (HFpEF) is a major health challenge affecting millions of people worldwide. Moreover, this disease presents multiple etiologies and associated comorbidities, leading to difficulties in diagnosis and limited therapeutic options. HFpEF underlying cellular...
ORGANISM(S): Homo sapiens (Human) 
2022-11-29 | PXD033876 | Pride
Heart failure with preserved ejection fraction  human myocardium ventricular samples  untargeted proteomics 
UnknownPlasma Biomarkers Reflecting Profibrotic Processes in Heart Failure With a Preserved Ejection Fraction: Data From the Prospective Comparison of ARNI With ARB on Management of Heart Failure With Preserved Ejection Fraction Study.
Not available
S-EPMC5485256 | biostudies-literature
ProteomicsCanagliflozin regulates ferroptosis to ameliorate heart failure in rats with preserved ejection fraction
Chronic heart failure (CHF), with whether reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF), is the end-stage of various cardiovascular diseases and severely affects the patients’ lifespan. There has been no effective drugs to improve clinical outcomes for a long time. Sine th...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-05-20 | PXD029031 | Pride
Sodium-glucose cotransporter 2 inhibitor Canagliflozin Heart failure Ferroptosis Lipid peroxidation 
GenomicsChromatin Remodelers in Cardiometabolic Heart Failure with Preserved Ejection Fraction
Chromatin Remodelers in Cardiometabolic Heart Failure with Preserved Ejection Fraction
PRJNA1222300 | ENA
ProteomicsProteomics of epicardial adipose tissue in heart failure patients with preserved ejection fraction
Background: Heart failure with preserved ejection fraction (HFpEF) has become a major public health problem with a morbidity and mortality similar to heart failure with reduced ejection fraction (HFrEF). Recently, it has been proved epicardial adipose tissue (EAT) played an important role in the pat...
ORGANISM(S): Homo sapiens (Human) 
2023-01-30 | PXD028158 | Pride
Eat Hfpef Lc-msms 
ProteomicsHeart Failure with Preserved Ejection Fraction - Mouse Heart and Lung Tissue & Comorbidities
FASILOX analysis of heart and lung tissue form mice with heart failure with preserved ejection fraction and several comorbidities.
ORGANISM(S): Mus Musculus (mouse) 
2024-10-02 | PXD056447 | JPOST Repository
GenomicsHeart Failure Network – Imaging from Nitrate's Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction (HFN NEAT-Imaging)
Heart Failure Network – Imaging from Nitrate's Effect on Activity Tolerance in Heart Failure with Preserved Ejection Fraction (HFN NEAT-Imaging)
PRJNA1308190 | ENA
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