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MetabolomicsA multi-omics dataset of heat-shock response in the yeast RNA binding protein Mip6 (NMR assay)

Gene expression is a biological process regulated at different molecular levels, including chromatin accessibility, transcription, and RNA maturation and transport. In addition, these regulatory mechanisms have strong links with cellular metabolism. Here we present a multi-omics dataset that capt...

2020-02-14 | MTBLS1320 | MetaboLights
TranscriptomicsTranscription profiling of recombinant E. coli to heat-shock and dual heat-shock recombinant protein induction
Recombinant Escherichia coli cultures are used to manufacture numerous therapeutic proteins and industrial enzymes, where many of these processes use elevated temperatures to induce recombinant protein production. The heat-shock response in wild-type E. coli has been well studied. In this study, t...
ORGANISM(S): Escherichia coli 
2009-08-25 | E-GEOD-17507 | biostudies-arrayexpress
TranscriptomicsWidespread regulation of translation by elongation pausing in heat shock
RNA-seq and ribosome footprinting libraries of mouse 3T3 and human 293T cellsrelated to Shalgi et al. 2013 36bases paired-end RNA-seq, and ribosome footprinting libraries for: 3T3 cells - Control, 8 hours of mild heat shock (42) and 2 hours of severe heat shock (44) - in replicates, as well as 3T3 ...
ORGANISM(S): Mus musculus 
2013-01-03 | E-GEOD-32060 | biostudies-arrayexpress
TranscriptomicsDissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays
Regulation of the expression of heat-shock proteins plays an important role in the pathogenesis of Mycobacterium tuberculosis. The heat-shock response of bacteria involves genome-wide changes in gene expression. A combination of targeted mutagenesis and whole-genome expression profiling was used to ...
ORGANISM(S): Mycobacterium tuberculosis 
2007-03-07 | E-BUGS-2 | biostudies-arrayexpress
TranscriptomicsHeat shock: genomic run-on (GRO) analysis
This SuperSeries is composed of the following subset Series: GSE24483: TR heat-shock GSE24484: RA heat-shock Refer to individual Series
ORGANISM(S): Saccharomyces cerevisiae 
2011-04-19 | E-GEOD-24488 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of Escherichia coli O157:H7 EDL933 during heat shock using microarrays
The transcriptome of Escherichia coli K-12 has been widely studied over a variety of conditions for the past decade while such studies involving E. coli O157:H7, its pathogenic cousin, are just now being conducted. To better understand the impact of heat shock on E. coli O157:H7, global transcript l...
ORGANISM(S): Escherichia coli 
2009-04-01 | E-GEOD-11463 | biostudies-arrayexpress
ModelsSivery2016 - A mammalian heat shock response model
Environmental stress, such as oxidative or heat stress, induces the activation of the heat shock response (HSR) and leads to an increase in the heat shock proteins (HSPs) level. These HSPs act as molecular chaperones to maintain cellular proteostasis. Controlled by highly intricate regulatory mechan...
2022-01-25 | MODEL2201210001 | BioModels
TranscriptomicsChange in gene expression in Chlamydomonas reinhardtii upon heat shock
This was an accompanying experiment. Previously, the expression of genes hsp70A and hsp70B had been established as being tetrapyrrole-dependent (Kropat et al., 1997, 2000). Since both are well-known heat-shock proteins, we performed a one-step heat shock treatment by shifting the temperatures from 2...
ORGANISM(S): Chlamydomonas reinhardtii 
2011-03-02 | E-GEOD-20859 | biostudies-arrayexpress
TranscriptomicsSystemic Comparison of Heat Shock Response Induced by Heat Shock and a Proteasome Inhibitor in Mouse Fibrosarcoma Cells and Their Thermotolerant Counterparts
Heat shock response (HSR) is a cellular defense mechanism against various stresses. Both heat shock and proteasome inhibitor MG132 cause the induction of heat shock proteins, a distinct feature of HSR. To better understand the molecular basis of HSR, we subjected the mouse fibrosarcoma cell line, RI...
ORGANISM(S): Mus musculus 
2011-11-09 | E-GEOD-24197 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Arabidopsis Hsa32 mutant and wild type plants subjected to heat shock
Plants and animals share similar mechanisms in the heat-shock (HS) response, such as synthesis of the conserved HS proteins (Hsps). However, because plants are confined to a growing environment, in general they require unique features to cope with heat stress. We have analyzed the function of a nove...
ORGANISM(S): Arabidopsis thaliana 
2007-06-27 | E-GEOD-4062 | biostudies-arrayexpress
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