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MetabolomicsMapping the metabolism of five amino acids in bloodstream form Trypanosoma brucei using U-13C-labelled substrates and LC–MS
The metabolism of the parasite Trypanosoma brucei has been the focus of numerous studies since the 1940s. Recently it was shown, using metabolomics coupled with heavy-atom isotope labelled glucose, that the metabolism of the bloodstream form parasite is more complex than previously thought. The pres...
2019-06-24 | MTBLS624 | MetaboLights
MetabolomicsA novel micro-voltage driven fungal system for simultaneous removal of microplastics, antibiotics, and heavy metals

Microplastics, antibiotics, and heavy metals are co-occurring pollutants in wastewater, posing significant environmental risks and potential threats to human health. However, there is currently no effective wastewater treatment method for this type of combined pollution. This study establishes a ...

2026-01-05 | MTBLS13609 | MetaboLights
MetabolomicsApplication of the Protease-Resistant Antimicrobial Peptide R7I, Composed of Natural Amino Acids, as a Functional Food Ingredient for Modulating Intestinal Health

Foodborne pathogenic bacterial infections pose significant challenges to global food safety and public health, while the issue of antimicrobial resistance (AMR) has worsened in recent years, creating an urgent need for safe, natural alternatives to combat foodborne pathogens and associated intest...

2025-11-09 | MTBLS13292 | MetaboLights
ProteomicsAssessment of incorporation of heavy amino acids in mitochondrial gene deletion strains and wild-type cells
Knowledge about the functions of individual proteins on a systems-wide level is crucial to fully understand molecular mechanisms underlying cellular processes. A considerable part of the proteome across all organisms is still poorly characterized. Mass spectrometry is an efficient technology for the...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2020-01-24 | PXD010704 | Pride
Complete native stable isotope labeling by amino acids of saccharomyces cerevisiae for global proteomic analysis 
ProteomicsIncorporation of isotopically labeled amino acids in live mouse zygotes as means to understand the oocyte to embryo transition
A long-standing question in developmental and reproductive biology is when the mammalian embryo becomes sufficiently distinct from its oocyte precursor. Myriads of studies examined the messenger RNAs that change during the oocyte-to-embryo transition, whereas proteins have been much less studied, in...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-19 | PXD035570 | Pride
Blastocyst Proteomics Heavy amino acids Development Silac Mass spectrometry Oocyte Fertilization 
ProteomicsAmino acid and heavy water labelling to obtain protein turnover rates in intact adult animals
Both labelling studies were conducted with C57/BL6J adult male mice, derived from the same supplier and maintained under identical conditions. Eleven adult male C57BL/6JOlaHsd mice (Harlan UK Ltd., Shardlow, UK) of over 12 months of age at the start of the experiment were housed individually in 48 x...
ORGANISM(S): Mus Musculus (mouse) 
2021-12-13 | PXD029639 | JPOST Repository
TranscriptomicsCulture induced changes in Blood-Brain Barrier transcriptome: implications for amino acid transporters in vivo
Tight homeostatic control of brain amino acids (AA) depends on transport via solute family carrier proteins expressed by the Blood-Brain Barrier (BBB) microvascular endothelial cells (BMEC). To characterize the mouse BMEC transcriptome and probe culture-induced changes microarray analyses of PECAM-1...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-14375 | biostudies-arrayexpress
MetabolomicsPhotorespiration is linked to DNA methylation by formate as one-carbon source.
DNA methylation is a key epigenetic modification regulating genome organization, stability, and gene expression. Stable DNA methylation critically relies on methyl groups provided through folate-mediated one-carbon (C1) metabolism, yet the origin and regulation of C1 supply remain elusive. Here we d...
2026-01-06 | MTBLS13444 | MetaboLights
UnknownCombined interactions of amino acids and organic acids in heavy metal binding in plants.
Not available
S-EPMC9980588 | biostudies-literature
ProteomicsUncovering nutrient-regulated surface proteins using stable isotope labeling with amino acids in cell culture (SILAC) proteomics
The presence of a protein at the cell surface is regulated by the exocytic and endocytic membrane trafficking pathways. We have recently discovered that the nutrient, or amino acids, plays a substantial role in promoting the endocytic membrane trafficking. Here we ask if the nutrient can regulate t...
ORGANISM(S): Homo sapiens (Human) 
2019-04-03 | PXD011136 | Pride
Membrane trafficking Surface protein Silac Lc-ms/ms 
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