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TranscriptomicsWhole-genome methylation analysis (450k) of school aged children prenatally exposed to alcohol vs controls
We tested a hypothesis that prenatal alcohol exposure may lead to epigenetic alterations to the DNA resulting in attentional and cognitive alterations of the children. 6-9 year old children school children of the Franconian Cognition and Emotion Studies (FRANCES) cohort which were tested for an obj...
ORGANISM(S): Homo sapiens 
2018-05-12 | E-MTAB-6730 | biostudies-arrayexpress
UnknownThiol-selective native grafting from polymerization for the generation of protein-polymer conjugates.
Not available
S-EPMC11418805 | biostudies-literature
UnknownMetalloprotease meprin beta generates nontoxic N-terminal amyloid precursor protein fragments in vivo.
Not available
S-EPMC3149364 | biostudies-literature
ProteomicsThe effect of AKT and AMPK site-specific phosphorylation on TBC1D4 biological activity
TBC1D4 is a 160 kDa multi-domain containing RabGAP (Rab GTPase-activating protein) and a downstream target of the insulin and contraction-activated kinases AKT and AMPK. While phosphorylation of TBC1D4 has been linked to GLUT4 translocation from storage vesicles (GSVs) to the cell surface, its impac...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024621 | Pride
Lc-msms Tbc1d4 Protein phosphorylation 
ProteomicsAKT and AMPK site-specific phosphorylation on TBC1D4 biological activity
TBC1D4 is a 160 kDa multi-domain containing RabGAP (Rab GTPase-activating protein) and a downstream target of the insulin and contraction-activated kinases AKT and AMPK. While phosphorylation of TBC1D4 has been linked to GLUT4 translocation from storage vesicles (GSVs) to the cell surface, its impac...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-10 | PXD024645 | Pride
Lc-msms Partial digest Tbc1d4 
UnknownRecognising, quantifying and accounting for classification uncertainty in type 2 diabetes subtypes.
Not available
S-EPMC12423224 | biostudies-literature
ProteomicsHuman HDL 2D-LC-MS/MS
Besides modulation of reverse cholesterol transport, high density lipoprotein (HDL) is able to modulate vascular function by stimulating endothelial nitric oxide synthase. Recently, it could be documented that this function of HDL was significantly impaired in patients with chronic heart failure (CH...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-04-01 | MSV000080857 | MassIVE
TranscriptomicsClassification of a frameshift/extended and a stop mutation in WT1 as gain of function mutations which activate cell cycle genes and promote Wilms tumor cell proliferation
The Wilms tumor 1 (WT1) gene encodes a zinc finger transcription factor important for normal kidney development. WT1 is a suppressor for Wilms tumor development and an oncogene for diverse malignant tumors. We recently established cell lines from primary Wilms tumors and identified the corresponding...
ORGANISM(S): Homo sapiens 
2014-05-12 | E-GEOD-54635 | biostudies-arrayexpress
ProteomicsSustainability of specific improvements of cardiorespiratory fitness and insulin sensitive metabolism in type 2 diabetes after exercise training
High intensity interval training (HIIT) improves metabolism, but maybe with differences in sustainability between prediabetes and type 2 diabetes (T2D). We hypothesized that HIIT-induced changes are maintained after 4-week detraining in humans with (20 T2D) and without T2D (12 insulin-sensitive, IS-...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD046654 | Pride
Exercise  detraining  insulin sensitivity  mitochondrial function  small extracellular vesicles  inter-organ crosstalk 
ModelsWolf2001_Respiratory_Oscillations
This model by Jana Wolf et al. 2001 is the first mechanistic model of respiratory oscillations in Saccharomyces cerevisae. It is based on the assumption that feedback inhibition of cysteine on the sulfate transporters leads to oscillations in this pathway and causes oscillations in respiratory activ...
2024-09-02 | BIOMD0000000090 | BioModels
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