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MetabolomicsIdentification of Biomarkers using Metabolomics in Porcine Hemorrhagic Shock
Hemorrhagic shock with injury results in alterations of the metabolic state of an organism, which contribute to organ dysfunction and death. Previous investigations have explored the effects of carbohydrate prefeed in murine models but few in clinically relevant large animal models. We performed car...
2015-01-31 | MTBLS123 | MetaboLights
MetabolomicsDifferentiating Hemorrhagic Shock and Organophosphate Poisoning through Integrated Skin Microbiome–Metabolome Signatures

Accurate determination of cause of death and estimation of postmortem interval (PMI) are critical yet challenging tasks in forensic science, particularly in cases with rapid demise and minimal gross findings. We employed an integrative multi-omics approach to characterize postmortem microbial suc...

2026-06-01 | MTBLS14219 | MetaboLights
TranscriptomicsTranscription profiling of rat lung to investigate trauma hemorrhagic shock-induced lung injury: hemorrhage- and injury-associated genes
The etiology of trauma-hemorrhage shock-induced acute lung injury has been difficult to elucidate due, at least in part, to the inability of in vivo studies to separate the non-injurious pulmonary effects of trauma-hemorrhage from the tissue injurious ones. To circumvent this in vivo limitation, we...
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-6332 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response of murine liver to severe injury and hemorrhagic shock
This SuperSeries is composed of the following subset Series: GSE26695: Transcriptomic response of murine liver to severe injury and hemorrhagic shock: Affymetrix portion of dual platform GSE26696: Transcriptomic response of murine liver to severe injury and hemorrhagic shock: CodeLink portion of dua...
ORGANISM(S): Mus musculus 
2011-01-24 | E-GEOD-26697 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response of murine liver to severe injury and hemorrhagic shock: CodeLink portion of dual platform
A dual platform microarray analysis was used to characterize the temporal transcriptomic response in the mouse liver following trauma and hemmorhagic shock Mice were divided into five groups, anesthetized and surgically treated to simulate a time course and trauma severity model: non-manipulated ani...
ORGANISM(S): Mus musculus 
2011-01-24 | E-GEOD-26696 | biostudies-arrayexpress
ProteomicsPeptidomic Analysis of Hemorrhagic Shock Pig Plasma
A shotgun label-free quantitative proteomic approach was utilized to compare the peptidome of plasma samples from healthy and hemorrhagic shock pigs to verify the possible role of uncontrolled proteolytic activity in shock.
ORGANISM(S): Sus scrofa domesticus (domestic pig) 
2021-09-08 | PXD008018 | Pride
Plasma Peptidome Hemorrhagic shock Pig Lc-ms/ms 
TranscriptomicsGenome-Wide Expression Profiling Deciphers Host Responses Altered during Dengue Shock Syndrome and Reveals the Role of Innate Immunity in Severe Dengue
Background Deciphering host responses contributing to dengue shock syndrome (DSS), the life-threatening form of acute viral dengue infections, is required to improve both the differential prognosis and the treatments provided to DSS patients, a challenge for clinicians. Methodology/Principal Findin...
ORGANISM(S): Homo sapiens 
2010-07-21 | E-GEOD-17924 | biostudies-arrayexpress
TranscriptomicsAdvanced Age is Associated with Worsened Outcomes and a Unique Genomic Response in Severely Injured Patients with Hemorrhagic Shock
We performed epidemiological, cytokine, and transcriptomic analyses on a prospective, multi-center cohort of 1,928 severely injured patients. We wished to characterize the relationship of advanced age to clinical outcomes and to transcriptomic responses after severe blunt traumatic injury with hemor...
ORGANISM(S): Homo sapiens 
2015-01-06 | E-GEOD-64711 | biostudies-arrayexpress
TranscriptomicsTranscriptomic response of murine liver to severe injury and hemorrhagic shock: Affymetrix portion of dual platform
A dual platform microarray analysis was used to characterize the temporal transcriptomic response in the mouse liver following trauma and hemmorhagic shock Mice were divided into five groups, anesthetized and surgically treated to simulate a time course and trauma severity model: non-manipulated ani...
ORGANISM(S): Mus musculus 
2011-01-24 | E-GEOD-26695 | biostudies-arrayexpress
TranscriptomicsIL-6-mediated activation of STAT3M-NM-1 prevents trauma/hemorrhagic shock-induced liver inflammation
We previously demonstrated in rodents that T/HS results in liver injury that can be prevented by IL-6 administration at the start of resuscitation, however the mechanism(s) for the IL-6 protective effect is not fully known. We used microarrays to detail the global gene expression in response to T/HS...
ORGANISM(S): Rattus norvegicus 
2011-03-16 | E-GEOD-27978 | biostudies-arrayexpress
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