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ProteomicsComparative proteome analysis of the tegument of male and female adult Schistosoma mansoni
We present a comparative analysis of sex-specific tegument proteins of paired or virgin Schistosoma mansoni. By apply a new and highly sensitive workflow, detection of even low abundance proteins from the worm was achieved Therefore, a streptavidin-biotin affinity purification technique in combinati...
ORGANISM(S): Schistosoma mansoni (Blood fluke) 
2022-05-20 | PXD031167 | Pride
Schistosoma manson Proteome Tegument 
ProteomicsMajor determinants of airway epithelial cell sensitivity to S. aureus alpha-toxin: Disposition of toxin heptamers by extracellular vesicle formation and lysosomal degradation
Alpha-toxin is a major virulence factor of Staphylococcus aureus and plays an important role in S. aureus-induced pneumonia. Different sensitivities toward the toxin of various host cell types have been observed. In this study we investigated internalization of pore-containing areas of the plasma me...
ORGANISM(S): Homo sapiens (Human) 
2021-04-20 | PXD023678 | Pride
Cellular sensitivity Alpha-toxin Airway epithelial cells Virulence factors Staphylococcus aureus Transmembrane pores 
ProteomicsComparative analysis of ChAdOx1 nCoV-19 and Ad26.COV2.S SARS-CoV-2 vector vaccines
Vector-based SARS-CoV-2 vaccines such as AstraZeneca's ChAdOx1 nCoV-19 have been associated with vaccine-induced thrombosis (TTS/VITT). We studied ChAdOx1 nCov-19 (AstraZeneca) and Ad26.COV2.S (Johnson & Johnson) and compared the vaccines using proteomics with mass spectrometric measurements. We cou...
ORGANISM(S): Homo sapiens (Human) 
2023-05-04 | PXD027344 | Pride
Ad26.cov2.s Sars-cov-2 Vector vaccines Chadox1 
ProteomicsA Metaproteomics Approach to Elucidate Host and Pathogen Protein Expression during Catheter-Associated Urinary Tract Infections
Long term-catheterization leads inevitably to a catheter-associated bacteriuria caused by multispecies bacterial biofilms growing on and in the catheters. The overall goal of the presented study was (I) to unravel bacterial community structure and function of such an uropathogenic biofilm and (II) t...
ORGANISM(S): Morganella Homo sapiens (Human) Morganella Pseudomonas sp. 
2015-02-17 | PXD000164 | Pride
Metaproteomics 
ProteomicsComprehensive spectral library from the pathogenic bacterium Streptococcus pneumoniae with focus on phosphoproteins
In this study, a comprehensive spectral library for S. pneumoniae with an emphasis on phosphopeptide spectra was compiled. In total, 76% of the theoretical S. pneumoniae proteins were stored in a spectral library. Additionally, in combination with classical database search algorithms and the spectra...
ORGANISM(S): Streptococcus Pneumoniae D39 
MSV000084269 | MassIVE
ProteomicsMassSpecPreppy - an end-to-end solution for automated protein concentration determination and flexible sample digestion for proteomics applications
In proteomics, fast, efficient and highly reproducible sample preparation are of utmost importance, particularly in view of fast scanning mass spectrometers enabling analyses of large sample series. To address this need, we have developed the web application MassSpecPreppy that operates on the open ...
ORGANISM(S): Saccharomyces Cerevisiae Strain C13-aby.s86 Escherichia Coli K-12 (ncbitaxon:83333) Homo Sapiens (ncbitaxon:9606) 
2023-07-20 | MSV000092489 | MassIVE
ProteomicsA Metaproteomics Approach to Elucidate Host and Pathogen Protein Expression during Catheter-Associated Urinary Tract Infections
Long term-catheterization leads inevitably to a catheter-associated bacteriuria caused by multispecies bacterial biofilms growing on and in the catheters. The overall goal of the presented study was (I) to unravel bacterial community structure and function of such an uropathogenic biofilm and (II) t...
ORGANISM(S): Morganella <scale Insect> (ncbitaxon:108061) Morganella <fungus> (ncbitaxon:90690) Pseudomonas Sp. (ncbitaxon:306) Homo Sapiens (ncbitaxon:9606) 
2016-07-19 | MSV000079927 | MassIVE
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