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ProteomicsProteomic analysis of Hepatocellular Adenoma
Hepatocellular adenomas (HCA) are rare benign tumors that constitute a heterogeneous entity, divided into 5 groups based on molecular features (1) H-HCA with inactivating mutations of Hepatocyte Nuclear Factor 1A (HNF1α), (2) inflammatory HCA (IHCA) with diverse mutations activating the JAK/STAT pat...
ORGANISM(S): Homo sapiens (Human) 
2018-03-14 | PXD005571 | Pride
Lc-msms Quantitative proteome Liver Hemorrhage risk Arginine metabolism Hepatocellular adenoma 
TranscriptomicsHNF1-alpha inactivation promotes lipogenesis in human hepatocellular adenoma independently of SREBP1 & ChREBP activation
Biallelic inactivating mutations of the transcription factor 1 gene (TCF1), encoding hepatocyte nuclear factor 1a (HNF1a), were identified in 50% of hepatocellular adenomas (HCA) phenotypically characterized by a striking steatosis. To understand the molecular basis of this aberrant lipid storage, w...
ORGANISM(S): Homo sapiens 
2007-05-01 | E-GEOD-7473 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of dab hepatocellular adenoma liver tumours (Limanda limanda)
A custome-made 8x15k oligonucleotide limanda limanda microarray (Agilent) comprised of 14919 experimental probes, was used to characterize gene expression profiles of dab hepatocellular adenoma tumours from sites of different pollution status in Irish Sea.
ORGANISM(S): Limanda limanda 
2011-11-04 | E-MTAB-734 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of 57 hepato cellular carcinoma tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools
A ""Cartes d'Identite des Tumeurs"" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 65 samples on Affymetrix HG-U133A GeneChips arrays (57 tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools). Identification of six subgroups of Hepatocellular...
ORGANISM(S): Homo sapiens 
2007-03-26 | E-TABM-36 | biostudies-arrayexpress
GenomicsWGS/RNA-seq pair of an inflammatory hepatocellular adenoma (IHCA)
A 49 years old female patient consulted for diarrhea, rectal bleeding and lower limbs edema and was diagnosed with systemic AA amyloidosis. An inflammatory hepatocellular adenoma was further identified and resected, resulting in the improvement of amyloidosis-related symptoms. Molecular analyses of ...
EGAS00001003025 | EGA
TranscriptomicsRNA-seq of human hepatocellular carcinoma (HCC) patients
Tumor samples and matching healthy tissue from 23 human hepatocellular carcinoma (HCC) patients and one hepatocellular adenoma patient were collected after surgical resection. Total RNA was harvested and sequenced with a strand-specific single-end RNA-seq protocol.
ORGANISM(S): Homo sapiens 
2021-12-23 | E-MTAB-8915 | biostudies-arrayexpress
GenomicsIntegrative genomic profiling of hepatocellular adenomas reveals recurrent FRK activating mutations and mutational processes of malignant transformation
Hepatocellular adenomas (HCA) are benign liver tumors predominantly developed in women using oral contraception. Here, exome sequencing identified novel recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation and cell proliferation sensitive to Src inhibitors. We a...
EGAS00001000679 | EGA
GenomicsA new subgroup of hepatocellular adenomas with sonic hedgehog pathway activation
Hepatocellular adenomas (HCA) are benign liver tumors divided in molecular subtypes characterized by mutations inactivating HNF1A, activating β-catenin or the IL-6/JAK/STAT inflammatory pathway. Molecular analyses of 533 HCA developed in 411 patients identified a new tumor subgroup with Sonic Hedgeh...
EGAS00001002091 | EGA
GenomicsCytogenetic aberrations in Hepatocellular adenoma and carcinoma
Cytogenetic aberrations in Hepatocellular adenoma and carcinoma
PRJNA266614 | ENA
TranscriptomicsTranscription profiling by array of human Intrahepatic Cholangiocarcinoma (ICC) and Combined Hepatocellular Cholangiocarcinoma (CHC) tumors
We compared transcriptomic profiles of 23 ICC tumor specimens to hepatocellular carcinoma (HCC) specimens using Affymetrix mRNA array and the miRNA array platforms to search for unique gene signatures linked to patient prognosis. ICC and HCC share common stem-like molecular characteristics and stem-...
ORGANISM(S): Homo sapiens 
2012-09-28 | E-GEOD-32879 | biostudies-arrayexpress
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