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TranscriptomicsTranscription profiling of 57 hepato cellular carcinoma tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools
A ""Cartes d'Identite des Tumeurs"" (CIT) project from the french Ligue Nationale Contre le Cancer (http://cit.ligue-cancer.net). 65 samples on Affymetrix HG-U133A GeneChips arrays (57 tumoral samples, 3 hepatocellular adenomas, 5 non-tumoral pools). Identification of six subgroups of Hepatocellular...
ORGANISM(S): Homo sapiens 
2007-03-26 | E-TABM-36 | biostudies-arrayexpress
GenomicsA new subgroup of hepatocellular adenomas with sonic hedgehog pathway activation
Hepatocellular adenomas (HCA) are benign liver tumors divided in molecular subtypes characterized by mutations inactivating HNF1A, activating β-catenin or the IL-6/JAK/STAT inflammatory pathway. Molecular analyses of 533 HCA developed in 411 patients identified a new tumor subgroup with Sonic Hedgeh...
EGAS00001002091 | EGA
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (5)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 ...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD023000 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (4)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 c...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD022844 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (1)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 c...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD022835 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (2)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 c...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD022837 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsDiagnosis of hepatocellular adenomas and malignancy determination by proteomic patterns matching (3)
Biopsies are underrated and underused and our goal was to demonstrate that their inherent expression proteomic pattern could give them an added value for diagnosis. As proof of concept, we used as model hepatocellular adenomas (HCA), well characterized benign liver tumors. From a collection of 260 c...
ORGANISM(S): Homo sapiens (Human) 
2021-06-11 | PXD022839 | Pride
Patterns matching Biopsies Machine learning Clinical proteomics Diagnosis Hepatocellular adenomas Malignancy 
ProteomicsCharacterization of tumor heterogeneity in beta-catenin mutated hepatocellular adenomas
Hepatocellular adenomas (HCA) are rare benign tumours of the liver which have been extensively classified at the clinico-pathological, genetic and proteomic levels. The b-HCA subtype has several types of mutations in the ß-catenin gene (CTNNB1) with very different clinical phenotypes and risks. Rece...
ORGANISM(S): Homo sapiens (Human) 
2023-05-02 | PXD031323 | Pride
Laser microdissection Tumor heterogeneity Proteomics Hepatocellular adenomas 
GenomicsIntegrative genomic profiling of hepatocellular adenomas reveals recurrent FRK activating mutations and mutational processes of malignant transformation
Hepatocellular adenomas (HCA) are benign liver tumors predominantly developed in women using oral contraception. Here, exome sequencing identified novel recurrent somatic FRK mutations that induce constitutive kinase activity, STAT3 activation and cell proliferation sensitive to Src inhibitors. We a...
EGAS00001000679 | EGA
TranscriptomicsFrequent in-frame somatic deletions activate gp130 in inflammatory hepatocellular tumours
Inflammatory hepatocellular adenomas (IHCA) are benign liver tumours defined by the presence of inflammatory infiltrates and by the elevated expression of inflammatory proteins in tumour hepatocytes1,2. Here we show a striking activation of the IL6 signalling pathway in this tumour type, and sequenc...
ORGANISM(S): Homo sapiens 
2008-12-24 | E-GEOD-11819 | biostudies-arrayexpress
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