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MetabolomicsMetabolic Reprogramming in Tumor-Associated Macrophages during Murine Hepatocellular Carcinoma Progression

To investigate the impact of Wdr4 on the metabolic reprogramming of tumor-associated macrophages (TAMs) in hepatocellular carcinoma (HCC), we established an orthotopic HCC model in Wdr4-f/f and Wdr4 conditional knockout (Wdr4-cKO) mice. TAMs were subsequently isolated via flow cytometry-based cel...

2025-09-28 | MTBLS12764 | MetaboLights
MetabolomicsReal-world neonicotinoid mixture exposure reveals synergistic cytotoxicity and divergent pathway vulnerabilities in human cell lines

In this study, five human cell lines (A2780, Chang liver, HEK293T, HeLa, and HepG2) were used as models and exposed to mixtures of neonicotinoids (NEOs) and their metabolites. The mixture concentrations were prepared based on human biomonitoring data to reflect the actual detected levels of NEOs ...

2026-06-22 | MTBLS13896 | MetaboLights
TranscriptomicsmRNA and RNC-mRNA deep sequencing of three hepatocellular carcinoma cell lines
We sequenced the total mRNA and translating mRNA (RNC-mRNA) of three hepatocellular carcinoma cell lines Hep3B, HCCLM3 and MHCC97H For each cell line, samples prepared from three independent and identical cell cultures were pooled with equal amounts. C-HPP China Team
ORGANISM(S): Homo sapiens 
2014-02-18 | E-GEOD-49994 | biostudies-arrayexpress
TranscriptomicsmicroRNA profiling of human hepatocellular carcinoma
microRNA profiling of 89 human hepatocellular carcinoma tissues using bead-based technology. microRNA expression profiling was performed using freshly frozen hepatocellular carcinoma tissues obtained at the time of surgical treatment.
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-20594 | biostudies-arrayexpress
Transcriptomicscomparison of mRNA expression among rat hepatoma cell lines with different metastatic ability
To reduce cancer mortality, understanding of mechanisms of cancer metastasis is crucial. We have established 6 rat hepatocellular carcinoma (HCC) cell lines, which exhibit differing metastatic potential to the lung after inoculation into the tail veins of nude mice. Micorarray analysis of 4 kinds of...
ORGANISM(S): Rattus norvegicus 
2012-06-20 | E-GEOD-30469 | biostudies-arrayexpress
TranscriptomicsGene-expression profiles of formalin-fixed, paraffin-embedded human hepatocellular carcinoma
Gene-expression profiles of formalin-fixed, paraffin-embedded human hepatocellular carcinoma tissues obtained at the time of surgical resection. Gene-expression profiling was performed using formalin-fixed, paraffin-embedded hepatocellular carcinoma tissues obtained at the time of surgical resection...
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-19977 | biostudies-arrayexpress
ProteomicsProteome of Human hepatocellular carcinoma cell lines
The proteomic profiling of nine commonly used HCC cell lines Hep3B, HepG2, HepG2.2.15, HUH7, PLC/PRF/5, MHCC97L,MHCC97H,HCCLM3 and HCCLM6
ORGANISM(S): Homo sapiens (Human) 
2022-11-11 | PXD036643 | Pride
Hepatocellular carcinoma cell lines 
ProteomicsVARS1 overexpression in hepatocellular carcinoma cell lines
VARS1 was transiently overexpressed in Hep3B and SNU-387 hepatocellular carcinoma-derived cell lines.
ORGANISM(S): Homo sapiens (Human) 
2024-12-02 | PXD056392 | Pride
Vars1 Hepatocellular carcinoma Liver 
TranscriptomicsTranscription profiling of human hepatocellular carcinoma reveals common molecular subtypes
Hepatocellular carcinoma (HCC) is a common malignancy with high mortality due to a lack of effective therapies. HCC represents a collection of highly heterogeneous tumor types but a general molecular classification of HCC is lacking. Here, we define three molecular subtypes of HCC that are observed ...
ORGANISM(S): Homo sapiens 
2009-09-17 | E-GEOD-10393 | biostudies-arrayexpress
TranscriptomicsMicroRNA-Based Classification of Hepatocellular Carcinoma and Oncogenic Role of miR-517a
Hepatocellular carcinoma (HCC) is a complex and heterogeneous tumor due to activation of multiple cellular pathways and molecular alterations. Herein, we report the first molecular classification of 89 HCC based on the expression of 358 microRNAs and integrative genomic analysis. Three main subclass...
ORGANISM(S): Homo sapiens 
2011-02-17 | E-GEOD-20596 | biostudies-arrayexpress
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