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ProteomicsDNA polymerase kappa is the primary translesion synthesis polymerase for aldehyde ICLs
DNA interstrand crosslinks (ICLs) are highly cytotoxic lesions that block essential cellular processes like replication and transcription. Endogenous ICLs can be induced by reactive aldehydes produced during normal cellular metabolism. Defective repair of these aldehyde-induced ICLs is associated wi...
ORGANISM(S): Xenopus laevis (African clawed frog) 
2025-09-29 | PXD066315 | Pride
Dna polymerase kappa Acrolein-icl Translesion synthesis Fanconi anemia pathway Acetaldehyde-icl 
ProteomicsPRC2 loss impairs small cell lung cancer tumorigenesis and enhances sensitivity to G9a/GLP inhibition
Effective targeted therapies remain a major challenge for patients with small cell lung cancer (SCLC). Targeting the epigenome of SCLC to address immune evasion and chemoresistance offers a promising strategy to improve treatment outcomes. In this study, we investigate the role of Polycomb repressiv...
ORGANISM(S): Homo sapiens (Human) 
2025-12-16 | PXD067850 | Pride
Small cell lung cancer Combination therapy Preclinical models Eed Ezh2 Targeted therapy 
ProteomicsMapping functional non-coding variation in individual human genomes through haplotyping, multiomics, and deep learning
Most genetic variants in the human genome reside in non-coding regions, where they can perturb regulatory elements, influence gene expression, and contribute to various phenotypes and diseases. However, identifying such functionally relevant genetic variation remains challenging. Here we integrate p...
ORGANISM(S): Homo sapiens (Human) 
2026-04-22 | PXD069116 | Pride
Lc-msms Non-coding variants Deep learning 
ProteomicsDynamic regulatory grammar of human promoters uncovered by MPRA-trained deep learning
One of the major challenges in genomics is to build computational models that accurately predict genome-wide gene expression from the sequences of regulatory elements. Promoters play a key role in gene regulation, yet their regulatory logic remains incompletely understood. Here, we present PARM, a c...
ORGANISM(S): Homo sapiens (Human) 
2026-01-14 | PXD072017 | Pride
Synthetic biology Massively parallel reporter assay Convolutional neural network Promoter Gene regulation Transcription factor Deep learning in genomics. Genetics 
UnknownPolyphenol-rich strawberry extract protects human dermal fibroblasts against hydrogen peroxide oxidative damage and improves mitochondrial functionality.
Not available
S-EPMC6270910 | biostudies-literature
UnknownValidation of the RIM Score-COVID in the Spanish SEMI-COVID-19 Registry.
Not available
S-EPMC9862219 | biostudies-literature
UnknownAberrant gene promoter methylation associated with sporadic multiple colorectal cancer.
Not available
S-EPMC2808250 | biostudies-literature
UnknownReal-world Effectiveness and Safety of Bictegravir/Emtricitabine/Tenofovir Alafenamide in Comparison With Other Regimens in People With HIV Starting Therapy With AIDS-Defining Conditions: Results From the CoRIS Cohort-The ACTUAS II Study.
Not available
S-EPMC12596416 | biostudies-literature
UnknownLong-term effectiveness and tolerability of dolutegravir/lamivudine in treatment-naive people with HIV: an analysis of a multicentre cohort at 96 weeks.
Not available
S-EPMC11879157 | biostudies-literature
UnknownShould we measure quality of life among people with HIV? A multicentre survey of physicians' opinions in Spain.
Not available
S-EPMC11786618 | biostudies-literature
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