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TranscriptomicsCo-activator function of RIP140 for NFκB/p65-dependent cytokine gene
High- and low-grade inflammatory responses represent a hallmark of numerous pathologies such as sepsis and bacterial infection or insulin resistance and obesity, respectively. Here we describe an unexpected co-activator function of receptor interacting protein (RIP) 140 for nuclear factor (NF) kB, a...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-10386 | biostudies-arrayexpress
ProteomicsLipocalin 13 enhances insulin secretion but is dispensable for systemic metabolic control
Members of the lipocalin protein family serve as biomarkers for kidney disease and acute phase inflammatory reactions, and are under pre-clinical development for the diagnosis and therapy of allergies. However, none of the lipocalin family members has made the step into clinical development, mostly ...
ORGANISM(S): Mus musculus (Mouse) 
2021-02-02 | PXD022682 | Pride
Lipocalin 13 Metabolic diseases Type 2 diabetes Hepatokine Obesity 
ProteomicsFasting-sensitive SUMO-switch on Prox1 controls hepatic cholesterol metabolism
Accumulation of excess nutrients hampers proper liver function and is linked to non-alcoholic fatty liver disease (NAFLD) in obesity. However, the signals responsible for an impaired adaptation of hepatocytes to obesogenic dietary cues remain still largely unknown. Post-translational modification b...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD041329 | Pride
Prox1 Sumoylation Cholesterol Liver Bile acids 
ProteomicsProteomics on Inhibition of ceramide synthesis in the context of cachexia
Cachexia is a metabolic wasting syndrome affecting most of cancer patients. Disturbed lipid metabolism is a cachexia hallmark, and our previous work has identified increased levels of circulating ceramides, bioactive lipids with established functions in metabolic diseases, as biomarkers for cachexia...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-24 | PXD062072 | Pride
TranscriptomicsBrown Adipose Tissue Harbors a distinct subpopulation of regulatory T cells
Regulatory T (Treg) cells are critical determinants of both immune responses and metabolic control. Here we show that systemic ablation of Treg cells compromised the adaptation of whole-body energy expenditure to cold exposure, correlating with impairment in thermogenic marker gene expression and ma...
ORGANISM(S): Mus musculus 
2015-06-23 | E-GEOD-64909 | biostudies-arrayexpress
TranscriptomicsTranscriptional co-factor Transducin beta-like (TBL) 1 acts as a checkpoint in pancreatic cancer malignancy
Pancreatic ductal adenocarcinoma (PDAC) is the fourth leading cause of cancer fatalities in Western societies, characterized by high metastatic potential and resistance to chemotherapy. Critical molecular mechanisms of these phenotypical features still remain unknown, thus hampering the development ...
ORGANISM(S): Homo sapiens 
2015-06-16 | E-GEOD-59761 | biostudies-arrayexpress
TranscriptomicsTranscriptional co-factor TBLR1 controls lipid mobilization in white adipose tissue
Lipid mobilization (lipolysis) in white adipose tissue (WAT) critically controls lipid turnover and adiposity in humans. While the acute regulation of lipolysis has been studied in detail, the transcriptional determinants of WAT lipolytic activity remain still largely unexplored. Here we show that ...
ORGANISM(S): Mus musculus 
2013-04-01 | E-GEOD-43658 | biostudies-arrayexpress
TranscriptomicsCachexia-inducible Transforming growth factor-beta1 stimulated Clone-22 D4 controls acute hepatic lipid homeostasis.
To explore the molecular basis for TSC22D4 function in hepatic lipid homeostasis in vivo TSC22D4 was knocked down in the mouse liver using adenovirus and performed genome wide expression analysis. 1x10^9 plaque-forming units (pfu) per recombinant virus were administered via tail vein injection. Mice...
ORGANISM(S): Mus musculus 
2012-09-01 | E-GEOD-33324 | biostudies-arrayexpress
TranscriptomicsTransforming growth factor beta-like stimulated clone 22 D4 promotes diabetic hyperglycemia and insulin resistance [abdominal fat]
Obesity-related insulin resistance represents the core component of the so-called Metabolic Syndrome, ultimately promoting glucose intolerance, pancreatic beta cell failure, and overt type 2 diabetes 1 2. Based on substantial side effects of existing pharmacological approaches, efficient and safe in...
ORGANISM(S): Mus musculus 
2014-10-15 | E-GEOD-53753 | biostudies-arrayexpress
UnknownMitochondrial DNA analysis shows a Near Eastern Neolithic origin for domestic cattle and no indication of domestication of European aurochs.
Not available
S-EPMC2176208 | biostudies-literature
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