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BACKGROUND: Cervical carcinoma develops as a result of multiple genetic alterations. Different studies investigated genomic alterations in cervical cancer mainly by means of metaphase comparative genomic hybridization (mCGH) and microsatellite marker analysis for the detection of loss of heterozygos...
ORGANISM(S): Homo sapiens 
Genome-wide SNP profilling for loss of heterozygosity (LOH) during FOXM1B-induced malignant transformation in a human premalignant oral keratinocyte line SVpgC2a. Experiment Overall Design: Eight FOXM1B-induced malignant clones (SVFN1-8) that grew in soft agar were grown as individual cell lines and...
ORGANISM(S): Homo sapiens 
Early B cell factor 1 (EBF1) is one of the key transcription factors required for orchestrating B-cell lineage development. Although studies have shown that Ebf1 haploinsufficiency is involved in the development of leukemia, no study has been conducted that characterizes the global effect of Ebf1 he...
ORGANISM(S): Mus musculus (Mouse) 
2017-12-20 | PXD008396 | Pride
Loss of heterozygosity drives adaptation in hybrid yeast
Chromosome arm deletions are frequently observed in human cancers. Such large-scale aberrations may trigger phenotypes distinct from those that arise by loss of single genes. Using TALEN-based genomic engineering, we generated cell models with targeted 8p loss-of-heterozygosity (LOH) that mimics an ...
ORGANISM(S): Homo sapiens 
Pan cancer investigation of human leukocyte antigen loss of heterozygosity
Pan cancer investigation of human leukocyte antigen loss of heterozygosity
We analysed, by last-generation high-resolution SNP arrays, Normal Karyotype (NK)-AML patients at diagnosis (Dx) and remission (R) phases, in order to determine the number of tumor-associated copy number abnormalities (CNAs) and copy neutral-loss of heterozygosity (CN-LOH) regions per patient and to...
ORGANISM(S): Homo sapiens 
Effect of DGCR8 knockout and heterozygosity pri-miRNA processing in PA-1 cells
CGH arrays for Smukowski Heil, et al MBE 2017. Hybridization is often considered maladaptive, but sometimes hybrids can invade new ecological niches and adapt to novel or stressful environments better than their parents. The genomic changes that occur following hybridization that facilitate genome r...
ORGANISM(S): Saccharomyces x bayanus Saccharomyces cerevisiae Saccharomyces uvarum Saccharomyces cerevisiae x Saccharomyces uvarum 
2017-02-21 | GSE95086 | GEO
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