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ProteomicsDeep phenotyping of SH-Sy5y cells exposed to glucosylsphingosine by LC-MS
SH-Sy5y cells were exposed to glucosylsphingosine (GlcSph) at two concentrations observed in moderate (20 ng/mL) and severe (200 ng/mL) Gaucher disease phenotypes and subjected to label free proteomics to identify cellular pathways and molecules affected by GlcSph. Lyso-Gb3, a lipid accumulating in ...
ORGANISM(S): Homo sapiens (Human) 
2025-09-01 | PXD061666 | Pride
Sh-sy5y Lc-ms Glucosylsphingosine Gaucher disease 
Proteomics2D Spatial Proteomic Mapping Shows Distinct Regional Differences in the Bovine Cardiac Proteome
This study highlights that organs can have variable sub-proteomes that do not necessarily correspond to anatomical features. The bovine heart as a model demonstrates at least 3-5 separate proteomes exist within a 2D plane of the heart. The main differences between these proteomes were the biochemica...
ORGANISM(S): Bos taurus (Bovine) 
2024-10-17 | PXD013375 | Pride
Heart Desmoglein 2 Proteomics Bovine Mitochondria Proteome 
ProteomicsA multiplexed urinary biomarker panel has potential for Alzheimer’s Disease Diagnosis using targeted proteomics and machine learning
As disease-modifying therapies are now available for Alzheimer’s disease (AD), accessible, accurate and affordable biomarkers to support diagnosis are urgently needed. We sought to develop a mass spectrometry-based urine test as a high-throughput screening tool for diagnosing AD. We collected urine...
ORGANISM(S): Homo Sapiens 
2026-05-04 | PXD044751 | panorama
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