Sort   by:  
 Page size 
MetabolomicsHighly sensitive feature detection for high resolution LC/MS

BACKGROUND: Liquid chromatography coupled to mass spectrometry (LC/MS) is an important analytical technology for e.g. metabolomics experiments. Determining the boundaries, centres and intensities of the two-dimensional signals in the LC/MS raw data is called feature detection. Fo...

2020-01-15 | MTBLS1430 | MetaboLights
MetabolomicsBridging Targeted (Zeno MRM-HR) and Untargeted (SWATH) LC–HRMS in a Single Run for Sensitive Exposomics

Traditionally, chemical exposure has been assessed by low-resolution mass spectrometry via targeted approaches due to the typically extremely low concentration of such compounds in biological samples. Nevertheless, untargeted approaches are now becoming a promising tool for a broader investigatio...

2025-08-28 | MTBLS10565 | MetaboLights
GenomicsA highly sensitive and robust method for genome-wide 5hmC profiling of rare cell populations
Investigations of 5-hydroxymethylcytosine (5hmC) in biologically and clinically samples and models with low cell numbers have been hampered by the low sensitivity and reproducibility using current 5hmC mapping approaches. Here, we develop a selective 5hmC chemical labeling approach using tagmentatio...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-77967 | biostudies-arrayexpress
ProteomicsHighly sensitive phosphoproteomics by tailoring solid-phase extraction to electrostatic repulsion-hydrophilic interaction chromatography
The dataset contains the data of key experiments for developing a novel and highly sensitive bottom-up phosphoproteomics strategy termed ERLIC-SCX/RP-LC-MS. We compared two SPE types (RP, SCX) for an ERLIC run with 7 fractions. The results were used to design a workflow for highly sensitive bottom-u...
ORGANISM(S): Homo sapiens (Human) 
2014-12-02 | PXD001381 | Pride
Phosphoproteomics Phosphopeptide enrichment Lc-ms Solid-phase extraction Scx Protein phosphorylation Rp 
OtherHighly sensitive phosphoproteomics by tailoring solid-phase extraction to electrostatic repulsion-hydrophilic interaction chromatography.
Data from ProteomeXchange, PXD ID: PXD001381. Experiment: ERLIC2, file: Velos02_06349 ERLIC2 F14.mzml. Published as part of Anal Chem. 2014 Nov 18 . From the Abstract: {{i}} ... Here we introduce a highly sensitive and easy-to-establish 2D bottom-up strategy for -g-scale phosphoproteomics, based on...
ORGANISM(S): Homo_sapiens_viruses, Human_female 
GPM32320005256 | GPMDB
Resource Reanalysis 
TranscriptomicsA Highly Sensitive and Unbiased Approach for Elucidating Antibody Repertoires
Developing B lymphocytes undergo V(D)J recombination to assemble germline V, D, and J gene segments into exons that encode the antigen-binding variable region of immunoglobulin (Ig) heavy (H) and light (L) chains. IgH and IgL chains associate to form the B cell receptor (BCR), which upon antigen bi...
ORGANISM(S): Mus musculus 
2016-07-22 | E-GEOD-82126 | biostudies-arrayexpress
GenomicsCEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq
CEL-Seq2: sensitive highly-multiplexed single-cell RNA-Seq
PRJNA313513 | ENA
ProteomicsSensitive profiling of cell surface proteome by using an optimized biotinylation method
Sensitive profiling of cell surface proteome by using an optimized biotinylation method
ORGANISM(S): Homo Sapiens (human) 
2023-02-02 | PXD039794 | JPOST Repository
ProteomicsOptimization of data-independent acquisition-MS for deep proteome analysis
Data-independent acquisition (DIA)-MS analysis overtops the existing data-dependent acquisition (DDA)-MS analysis enabling deep proteome coverage and precise relative quantitative analysis in single-shot LC-MS/MS. We constructed a single-shot LC-MS/MS system with an MS measurement time of 90 min for...
ORGANISM(S): Homo Sapiens (human) Cellular Organisms Mus Musculus (mouse) 
2019-10-28 | PXD016032 | JPOST Repository
TranscriptomicsLRH-1 governs vital transcriptional programs in endocrine sensitive and resistant breast cancer cells: Expression profiling
Tumor characteristics are decisive in the determination of treatment strategy for breast cancer patients. Patients with estrogen receptor-α (ERα) positive breast cancer can benefit from long-term hormonal treatment. Nonetheless, the majority of patients will develop resistance to these therapies. He...
ORGANISM(S): Homo sapiens 
2014-02-27 | E-GEOD-54891 | biostudies-arrayexpress
Sort   by:  
 Page size