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TranscriptomicsThe cell envelope stress response mediated by the LiaFSRLm three-component system of Listeria monocytogenes is controlled via the phosphatase activity of the bifunctional histidine kinase LiaSLm
Most members of the phylum Firmicutes harbor a two-component system, LiaSR, which is involved in the response to cell envelope stress elicited most notably by inhibitors of the lipid II cycle. In all LiaSR systems studied in detail LiaSR-mediated signal transduction was shown to be negatively contro...
ORGANISM(S): Listeria monocytogenes EGD-e 
2010-11-16 | E-GEOD-24107 | biostudies-arrayexpress
ProteomicsWidespread protein histidine phosphorylation in bacteria
For decades, extreme difficulties in analyzing histidine phosphorylation have limited the study of phosphohistidine signaling. Here we report a method revealing widespread and abundant protein histidine phosphorylation in E. coli. Our new approach generated the largest E. coli phosphoproteome datase...
ORGANISM(S): Escherichia Coli 
2017-12-07 | PXD008369 | JPOST Repository
TranscriptomicsTranscription profiling of Atlantic salmon fed with a low, medium or high histidine diet
Atlantic salmon at their 2nd year in sea were fed with a low, medium or high histidine diet (L, M, and H, respectively) for several months. Samples were taken at three time points, after the first, second and third period, and a number of fishes were assigned to a new feed group following a crossove...
ORGANISM(S): Salmon salar 
2009-03-27 | E-TABM-678 | biostudies-arrayexpress
Metabolomics4-Hydroxyphenanthrene exacerbates obesity by altering gut microbiota and bile acid metabolism

Elevated exposure to 4-hydroxyphenanthrenes (4-OHPhe) is positively associated with obesity risk. However, the specific pathogenic mechanism remains unclear. Here, we used SHapley Additive exPlanations (SHAP) and logistic regression analysis to identify a strong association between 4-OHPhe and o...

2025-12-21 | MTBLS13496 | MetaboLights
UnknownCrystal Structures of the histidine acid phosphatase from Francisella tularensis provide insight into substrate recognition.
Not available
S-EPMC2789666 | biostudies-literature
MetabolomicsSCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia
Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we used domain-focused CRISPR screening to identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...
2025-05-29 | MTBLS3707 | MetaboLights
UnknownThe Leishmania donovani histidine acid ecto-phosphatase LdMAcP: insight into its structure and function.
Not available
S-EPMC4687092 | biostudies-literature
UnknownFunctional characterization of two members of histidine phosphatase superfamily in Mycobacterium tuberculosis.
Not available
S-EPMC3866925 | biostudies-literature
TranscriptomicsConditional Essentiality of vicK (walKSpn) Histidine Kinase for Anaerobic Growth of Streptococcus pneumoniae D39
The VicRK two-component system of S. pneumoniae (Pneumococcus) is a member of the essential WalRK (YycFG) family found in low G+C gram positive bacteria. Previously, we showed that phosphorylated VicR response regulator (RR) is essential, because of its strong positive regulation of the pcsB gene, w...
ORGANISM(S): Streptococcus pneumoniae 
2013-01-04 | E-GEOD-19752 | biostudies-arrayexpress
TranscriptomicsGlobal profiling of gene expression in the ΔdigR and ΔsgmT mutant of Myxococcus xanthus
In Myxococcus xanthus 55% of the more than 250 two-component signal transduction systems (TCS) genes are orphan. We hypothesized that the histidine kinase SgmT and the response regulator DigR, which comprises a DNA binding domain of the HTH_Xer type, function together to regulate gene expression. We...
ORGANISM(S): Myxococcus xanthus 
2012-05-17 | E-GEOD-34408 | biostudies-arrayexpress
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