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ProteomicsGlobal and specific responses of the histone acetylome to systematic perturbation
Regulation of histone acetylation is fundamental to the utilisation of eukaryotic genomes in chromatin. Aberrant acetylation contributes to disease and can be clinically combated by inhibiting the responsible enzymes. Our knowledge of the histone acetylation system is patchy because we so far lacked...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2015-01-09 | PXD001394 | Pride
Lc-msms Histone acetylome Drosophila 
ProteomicsTime-resolved analysis reveals rapid dynamics and broad scope of the CBP/p300 acetylome
The acetyltransferases CBP and p300 are multifunctional transcriptional co-activators; however, their acetylation targets, site-specific acetylation kinetics, and function in proteome regulation are incompletely understood. We combined quantitative proteomics with novel CBP/p300-specific catalytic i...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) Mus Musculus (ncbitaxon:10090) 
MSV000095981 | MassIVE
GenomicsHistone acetylome-wide association study on tuberculosis infection
Epigenetic mechanisms are thought to play an important role in the pathogenesis of infectious diseases. Here, we describe the first histone acetylome-wide association study (HAWAS) of an infectious disease, based on genome-wide H3K27 acetylation profiling of peripheral granulocytes and monocytes fro...
EGAS00001003118 | EGA
GenomicsHistone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis
Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis
PRJNA814725 | ENA
ProteomicsAcetylome analysis of Bordetella pertussis reveals possible targets of novel BP0960 gene-encoded lysine deacetylase
Acetylation on ε-amino groups of lysine residues (N-ε-lysine acetylation) represents an important mechanism of post-translational regulation of protein function. However, its role and extent in the whooping cough agent Bordetella pertussis remain unknown. In this study, we analyzed the acetylomes of...
ORGANISM(S): Bacteria Bordetella pertussis (strain Tohama I / ATCC BAA-589 / NCTC 13251) 
2020-07-19 | PXD016384 | Pride
Acetylome Bordetella pertussis Deacetylase activity 
ProteomicsRegulation of cellular proteome and acetylome by catalytic and non-catalytic functions of class I histone deacetylases
Project description: Taking advantage of a newly generated model system, we examined the influence of class I HDAC catalytic and non-catalytic function on the cellular proteome and acetylome. Therefore, we generated HAP1 cell lines either lacking individual class I HDACs or expressing catalytically ...
ORGANISM(S): Homo sapiens (Human) 
2022-08-16 | PXD030164 | Pride
Acetylome Chromatin Hdac inhibitor Histone deacetylase 
ProteomicsQuantitative acetylome analysis reveals histone modifications that may predict prognosis in hepatitis B-related hepatocellular carcinoma
Lysine acetylation (Kac) as an important post-translational modification of histone is essential for gene expression regulation in hepatocellular carcinoma (HCC), however the atlas of whole acetylated proteins for HCC tissue and the difference of protein acetylation between human normal and HCC tiss...
ORGANISM(S): Homo Sapiens 
2020-10-24 | PXD022161 |
Proteomics: The Tip60 acetylome is a hallmark of the proliferative state in Drosophila
The acetyltransferase KAT5/Tip60 is a key epigenetic regulator of transcription and the DNA damage response. In Drosophila, Tip60 functions within the DOM-A complex to acetylate histones, but its broader substrate repertoire and cellular roles remain incompletely defined. Here, we comprehensively in...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-07-16 | PXD066107 | Pride
Acetylome Drosophila Tip60 Proliferation 
ProteomicsHigh intensity interval training remodels the proteome and acetylome in human skeletal muscle
Exercise is an effective strategy in the prevention and treatment of metabolic diseases. Alterations in the skeletal muscle proteome, including post-translational modifications, regulate its metabolic adaptations to exercise. Here, we examined the effect of high-intensity interval training (HIIT) on...
ORGANISM(S): Homo sapiens (Human) 
2022-06-09 | PXD023084 | Pride
Lysine acetylation Exercise Proteome Skeletal muscle Lcms 
ProteomicsAcetylome of Acinetobacter baumannii SK17 reveals a highly-conserved modification of histone-like protein HU
Lysine acetylation is a prevalent post-translational modification in both eukaryotes and prokaryotes. Whereas this modification is known to play pivotal roles in eukaryotes, the function and extent of this modification in prokaryotic cells remain largely unexplored. Here we report the acetylome of a...
ORGANISM(S): Acinetobacter baumannii 
2018-10-24 | PXD007289 | Pride
Acinetobacter baumannii Acetylome Lc msms 
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