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ProteomicsRegulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6 – HDX-MS dataset
Histone H3 lysine 36 methylation is a conserved histone modification that is critical for maintaining eukaryotic transcriptional fidelity and genomic stability. In yeast, this modification is catalyzed by Set2, an ortholog of the mammalian H3K36 methyltransferase SETD2. Previous genetic, biochemical...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2026-08-31 | PXD078353 | Pride
Structural proteomic Histone h3k36 methyltransferase set2 Hdx-ms 
ProteomicsPhosphorylation of methyltransferase Set2p and demethylase Jhd1p and its association with histone H3K36 methylation and stress response pathways in Saccharomyces cerevisiae
Histone lysine methylation is a key epigenetic modification that regulates eukaryotic transcription. In Saccharomyces cerevisiae, it is controlled by a reduced but evolutionarily conserved suite of methyltransferase (Set1p, Set2p, Dot1p, and Set5p) and demethylase (Jhd1p, Jhd2p, Rph1p, and Gis1p) en...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-03-07 | PXD029088 | Pride
Epigenetics Demethylase Signalling Histone methylation Yeast Chromatin Methyltransferase 
TranscriptomicsHistone H3K36 trimethylation is essential for multiple silencing mechanisms in fission yeast.
In budding yeast, Set2 catalyzes di- and trimethylation of H3K36 (H3K36me2 and H3K36me3) via an interaction between its SRI domain and C-terminal repeats of RNA polymerase II (Pol2) phosphorylated at Ser2 and Ser5 (CTD-S2,5-P). H3K36me2 recruits the Rpd3S histone deacetylase complex to repress crypt...
ORGANISM(S): Schizosaccharomyces pombe 
2016-02-04 | E-GEOD-66821 | biostudies-arrayexpress
GenomicsRegulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6 [ChIP-Seq]
Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6 [ChIP-Seq]
PRJNA1468607 | ENA
GenomicsRegulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6 [RNA-seq]
Regulation of the histone H3K36 methyltransferase Set2 by the histone chaperone Spt6 [RNA-seq]
PRJNA1468316 | ENA
TranscriptomicsMSL complex is attracted to genes marked by H3K36 trimethylation using a sequence-independent mechanism
In Drosophila, X chromosome dosage compensation requires the male-specific lethal (MSL) complex, which associates with actively transcribed genes on the single male X chromosome to upregulate transcription approximately 2-fold. We found that on the male X chromosome, or when MSL complex is ectopical...
ORGANISM(S): Drosophila melanogaster 
2007-09-20 | E-GEOD-8557 | biostudies-arrayexpress
GenomicsSplicing enhances recruitment of methyltransferase HYPB/Setd2 and methylation of histone H3 lysine 36
Several lines of recent evidence support a role for chromatin in splicing regulation. Here we show that splicing can also contribute to histone modification, which implies a bidirectional communication between epigenetics and RNA processing. Genome-wide analysis of histone methylation in human cell ...
ORGANISM(S): Homo sapiens 
2011-07-25 | E-GEOD-30902 | biostudies-arrayexpress
UnknownNucleosome and ubiquitin position Set2 to methylate H3K36.
Not available
S-EPMC6706414 | biostudies-literature
TranscriptomicsComparison of gene expression pattern between Wild-type and Setd2 knockout mESCs [Affymetrix]
SETD2/HYPB has been known as a histone H3K36 specific methyltransferase. However, its roles in physiology such as development and cellular function remain unclear. In this study, using mESCs as cellular model, we show that Setd2 mainly regulates differentiation of murine embryonic stem cells (mESCs)...
ORGANISM(S): Mus musculus 
2014-10-14 | E-GEOD-54931 | biostudies-arrayexpress
Transcriptomicsset2 buratowski lab
H3K36 methylation by Set2 targets Rpd3S histone deacetylase to 3’ transcribed regions, repressing internal cryptic promoters and slowing elongation. To further explore the function of this pathway, global transcription was analyzed in yeast experiencing a series of carbon source shifts. Many pr...
ORGANISM(S): Saccharomyces cerevisiae 
2016-09-25 | E-MTAB-4268 | biostudies-arrayexpress
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