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GenomicsIdentification of 67 histone marks and histone lysine crotonylation as a new type of histone modification
We report the identification of 67 previously undescribed histone modifications, increasing the current number of known histone marks by about 70%. We further investigated one of the marks, lysine crotonylation (Kcr), confirming that it represents an evolutionarily-conserved histone posttranslationa...
ORGANISM(S): Mus musculus 
2011-10-06 | E-GEOD-32663 | biostudies-arrayexpress
ProteomicsAn optimized and robust workflow for quantifying the canonical histone ubiquitination marks H2AK119ub and H2BK120ub by LC-MS/MS
The eukaryotic genome is packaged around histone proteins, which are subject to a myriad of post-translational modifications. By controlling DNA accessibility and the recruitment of protein complexes that mediate chromatin-related processes, these modifications constitute a key mechanism of epigenet...
ORGANISM(S): Homo Sapiens Mus Musculus 
2024-12-10 | PXD053212 | panorama
ProteomicsDevelopment of a high-throughput (10 minute microflow gradient) platform for quantitation of histone modifications on a new QTOF instrument
Histone post-translational modifications (PTMs) regulate gene expression patterns through epigenetic mechanisms. The 5 histone proteins (H1, H2A, H2B, H3, and H4) are extensively modified, with over 75 distinct modification types spanning more than 200 sites. Despite strong advances in mass spectrom...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-06 | MSV000094695 | MassIVE
ProteomicsDevelopment of a high-throughput (10 minute microflow gradient) platform for quantitation of histone modifications on a new QTOF instrument
Histone post-translational modifications (PTMs) regulate gene expression patterns through epigenetic mechanisms. The 5 histone proteins (H1, H2A, H2B, H3, and H4) are extensively modified, with over 75 distinct modification types spanning more than 200 sites. Despite strong advances in mass spectrom...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-05-06 | MSV000094696 | MassIVE
ProteomicsBreaking Boundaries in Histone Modification MS-based Detection: A Tailored Search Strategy for Unrestricted identification of novel epigenetic marks
Histone post-translational modifications (PTMs) are crucial for gene expression regulation and DNA maintenance, and their aberrations are linked to multiple diseases, like cancer. While functions related to lysine acetylation and methylation have been well-studied, recent studies have uncovered addi...
ORGANISM(S): Homo sapiens (Human) 
2025-11-11 | PXD061934 | Pride
Human Lc-msms Bioinformatics Epigenetics Histone post-translational modifications Open search 
GenomicsTDRD3 is an effector molecule for arginine methylated histone marks
Specific sites of histone tail methylation are associated with transcriptional activity at gene loci. These methyl-marks are interpreted by effector molecules, which harbor protein domains that bind the methylated motifs and facilitate either active or inactive states of transcription. CARM1 and PRM...
ORGANISM(S): Homo sapiens 
2011-01-06 | E-GEOD-22612 | biostudies-arrayexpress
ProteomicsDynamic changes of histone H3 marks during Caenorhabditis elegans lifecycle revealed by middle-down proteomics
We applied a middle-down proteomics strategy for large scale protein analysis during in vivo development of Caenorhabditis elegans. We characterized post-translational modifications (PTMs) on histone H3 N-terminal tails at eight time points during the C. elegans lifecycle, including embryo, larval s...
ORGANISM(S): Caenorhabditis elegans 
2015-11-02 | PXD002525 | Pride
C. elegans Lifecycle Post-translational modifications Histones Middle-down proteomics 
ProteomicsReader interactome of epigenetic histone marks in birds
Lysine methylation is part of the posttranscriptional histone code employed to recruit modification specific readers to chromatin. Unbiased, quantitative mass spectrometry approaches combined with peptide pull-downs have been used to study histone methylation-dependent binders in mammalian cells. He...
ORGANISM(S): Gallus gallus (Chicken) Taeniopygia guttata (Zebra finch) (Poephila guttata) 
2016-01-04 | PXD002282 | Pride
Histone Birds Lc-msms Interactome 
ProteomicsA strategy to characterize the global histone PTM landscape within tissues of non-model organisms
Histone post-translational modifications (PTMs) are epigenetic marks that play a critical role in the expression and maintenance of DNA, but they remain largely uninvestigated in non-model organisms due to technical challenges. To begin alleviating this issue, we developed a workflow for histone PTM...
ORGANISM(S): Oreochromis Mossambicus 
2024-02-29 | PXD040536 | panorama
ProteomicsData for: A practical guide for analysis of histone post-translational modifications by mass spectrometry: best practices and pitfalls
Histone proteomics from 5 human cell lines, discussed in publication: "A practical guide for analysis of histone post-translational modifications by mass spectrometry: best practices and pitfalls". Further explanation of data types, methods, and analysis are available in Data Explanation document in...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
MSV000084298 | MassIVE
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