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ProteomicsAdaptive epigenetic changes in histone variants and modifications rescue the fitness of Arabidopsis plants with dysfunctional histone chaperones
The aim was to characterize histone variants and PTMs in mutant plants with histone chaperone dysfunction using mass spectrometry-based approach. We found that the maintenance of genome stability via chromatin remodelling depends on a two-tiered process. The first level relies on a highly flexible m...
ORGANISM(S): Arabidopsis thaliana (Mouse-ear cress) 
2024-08-10 | PXD046034 | Pride
Arabidopsis Immunochemistry. Post-translational modifications Mass spectrometry Histone chaperone complex Chromatin remodeling Histone variants 
GenomicsMapping of somatic linker histone H1 variants in T47D-MTVL cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49334 | biostudies-arrayexpress
TranscriptomicsMapping of somatic linker histone H1 variants in T47D-MTVL and HeLa cells
At least six histone H1 variants exist in mammalian somatic cells that bind to the linker DNA and stabilize the nucleosome particle contributing to higher order chromatin compaction. In addition, H1 seems to be involved in the active regulation of gene expression. It is not well known whether the di...
ORGANISM(S): Homo sapiens 
2014-02-04 | E-GEOD-49333 | biostudies-arrayexpress
ProteomicsH2B variants expression during iAs-mediated EMT
This work details the first global mass spectrometric analysis of histone H2B variants as cells undergo arsenic-mediated epithelial to mesenchymal transition.
ORGANISM(S): Homo sapiens (Human) 
2016-05-17 | PXD003503 | Pride
Ion cyclotron resonance Proteomics Toxin Epigenetics Mass spectrometry Proteoform Transformation Top-down Fourier transform Inorganic arsenic Histone variants 
ProteomicsPosttranslational modification analysis of Histone H3t
Comprehensive posttranslational modifications in the testis-specific histone variant H3t protein validated in tagged knock-in mice.
ORGANISM(S): Mus Musculus (mouse) 
2024-09-13 | PXD052428 | JPOST Repository
ProteomicsH2A.Z histone variants facilitate HDACi-dependent removal of H3.3K27M mutant protein in paediatric high-grade glioma cells
Diffuse intrinsic pontine gliomas (DIPG) are a deadly paediatric brain tumours, non-resectable due to brainstem localisation and diffusive growth. Patients with DIPG have a dismal prognosis of 9-12 months of survival with no effective therapy. Over 80% of DIPGs harbour a mutation in histone 3 (H3.3 ...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-10-05 | MSV000093052 | MassIVE
TranscriptomicsGenome-wide analysis of histone H3.1 and H3.3 variants in Arabidopsis thaliana
Nucleosomes package eukaryotic DNA and are composed of four different histone proteins, H3, H4, H2A and H2B. Histone H3 has two main variants, H3.1 and H3.3, which show different genomic localization patterns in animals. We profiled H3.1 and H3.3 variants in the genome of the plant Arabidopsis thali...
ORGANISM(S): Arabidopsis thaliana 
2012-03-05 | E-GEOD-34840 | biostudies-arrayexpress
ProteomicsLabel free mass spectrometry-based quantification of linker histone H1 variants in clinical samples
Epigenetic aberrations have been recognized as important contributors to cancer onset and development, and increasing evidence suggests that linker histone H1 variants may serve as biomarkers useful for patient stratification, as well as play an important role as drivers in cancer. Although traditio...
ORGANISM(S): Mus musculus (Mouse) 
2021-03-16 | PXD020537 | Pride
Proteomics Mass spectrometry Label-free quantification Epigenetics Linker histone h1 Laser micro-dissection 
ProteomicsHistone H1 profiling in breast cancer samples
Epigenetic aberrations have been recognized as important contributors to cancer onset and development, and increasing evidence suggests that linker histone H1 variants may serve as biomarkers useful for patient stratification, as well as play an important role as drivers in cancer. Although traditio...
ORGANISM(S): Homo sapiens (Human) 
2021-03-16 | PXD020524 | Pride
Breast cancer Histone h1 
GenomicsIdentification of genetic variants that affect histone modifications in human cells
Histone modifications are important markers of function and chromatin state, yet the DNA elements that direct them to specific locations in the genome are poorly understood. Here we use the genetic variation in Yoruba lymphoblastoid cell lines as a natural experiment to identify genetic differences ...
ORGANISM(S): Homo sapiens 
2013-10-01 | E-GEOD-47991 | biostudies-arrayexpress
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