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TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders.
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2013-02-12 | E-GEOD-44266 | biostudies-arrayexpress
MetabolomicsSmall intestinal microbial dysbiosis underlies symptoms associated with functional gastrointestinal disorders
Small intestinal bacterial overgrowth (SIBO) has been implicated in symptoms associated with functional gastrointestinal disorders (FGIDs), though mechanisms remain poorly defined and treatment involves non-specific antibiotics. Here we show that SIBO based on duodenal aspirate culture reflects an o...
2019-04-30 | MTBLS876 | MetaboLights
TranscriptomicsToward a Better Understanding of Potential Roles of Astrocytes in HIV-1-associated Neurocognitive Disorders
We present a microarray analysis of primary mouse astrocytes exposed to HIV-1 in culture. Results are compared with previous genomic studies of HIV-1 effect in human astrocytes and human and macaque brains. Day-two neonatal mouse astrocytes were exposed in triplicates to cell-free HIV-1/NL4-3 at m.o...
ORGANISM(S): Mus musculus 
2009-08-05 | E-GEOD-17383 | biostudies-arrayexpress
ProteomicsHIV-Tat treatment of human neurons in vitro over time: towards a model for the molecular pathology of HIV-associated neurocognitive disorders (~70% cell culture confluence dataset)
We have used LC-MSMS discovery proteomics to identify the quantitative, cell-wide changes that occur when non-transformed, differentiated human neurons are treated with HIV-Tat over time. This may represent a novel cell culture model for initial HIV-associated neurocognitive disorder progression.
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD006332 | Pride
Hiv-tat Hiv associated neurocognitive disorders Human neuronal cells Lcmsms 
ProteomicsHIV-Tat treatment of human neurons in vitro over time: towards a model for the molecular pathology of HIV-associated neurocognitive disorders (~90% cell culture confluence dataset)
We have used LC-MSMS discovery proteomics to identify the quantitative, cell-wide changes that occur when non-transformed, differentiated human neurons are treated with HIV-Tat over time. This may represent a novel cell culture model for initial HIV-associated neurocognitive disorder progression.
ORGANISM(S): Homo sapiens (Human) 
2017-05-19 | PXD006314 | Pride
Hiv-tat Hiv associated neurocognitive disorders Human neuronal cells Lcmsms 
TranscriptomicsSignificant Effects of Antiretroviral Therapy on Global Gene Expression in Brain Tissues of Patients with HIV-Associated Neurocognitive Disorders
Antiretroviral therapy (ART) has reduced morbidity and mortality in HIV infection; however HIV-1-associated neurocognitive disorders (HAND) persist despite treatment. We used microarray analysis in post-mortem brain tissues to determine ART effectiveness in the brain and to identify molecular signat...
ORGANISM(S): Homo sapiens 
2011-09-24 | E-GEOD-28160 | biostudies-arrayexpress
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2012-12-07 | E-GEOD-42424 | biostudies-arrayexpress
MetabolomicsDisorders of gut microbiota and fecal-serum metabolic patterns are associated with pulmonary tuberculosis and pulmonary tuberculosis co-morbid type 2 diabetes mellitus

BACKGROUND: Pulmonary tuberculosis (PTB) and diabetes mellitus (DM) are prevalent chronic diseases with substantial implications for human health. DM patients are more susceptible to PTB, which exacerbates diabetes-related complications. However, the complex molecular mechanisms ...

2023-12-15 | MTBLS8729 | MetaboLights
TranscriptomicsDeregulation of microRNAs by HIV-1 Vpr protein leads to the development of neurocognitive disorders [differentiated SH-5Y cells]
Studies have shown that HIV-infected patients develop neurocognitive disorders characterized by neuronal dysfunction. The lack of productive infection of neurons by HIV suggests that viral and cellular proteins, with neurotoxic activities, released from HIV-1-infected target cells can cause this neu...
ORGANISM(S): Homo sapiens 
2013-01-17 | E-GEOD-43535 | biostudies-arrayexpress
ProteomicsPersistent Type I Interferon Signaling in the Brain of People with HIV under ART with Cognitive Impairment
To examine the mechanisms that drive persistent neuroinflammation, we analyzed the proteome from 27 HIV-infected brains on antiretroviral therapy (ART) with different stages of HIV-associated neurocognitive disorders (HAND) by tandem mass tag quantitative proteomics. We observed that 73.3% of the up...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD042550 | Pride
Ifn Hiv-associated neurocognitive disorders (hand) Proteome 
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