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GenomicsSequencing Apoptotic DNA Breakpoints
DNA fragmentation is a well-recognized hallmark of apoptosis. However, the precise DNA sequences cleaved during apoptosis triggered by distinct mechanisms remain unclear. We used next-generation sequencing of DNA fragments generated in Actinomycin D-treated human HL-60 leukemic cells to generate a h...
ORGANISM(S): Homo sapiens 
2011-10-15 | E-GEOD-32997 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human HL-60 leukemia cells after treatment with Curcumin and TCDD
Curcumin has antileukemic potential that is mediated by dfifferent pathways. Because we could not confirm that the Arylhydrocarbonreceptor, a ligand activated transcription factor, is involved in curcumins antileukemic effects, we performed microarray experiments to have an overall screening of the ...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-GEOD-16160 | biostudies-arrayexpress
TranscriptomicsHuman HL-60 Cells: all-trans retinoic acid (ATRA) vs. ATRA plus arsenic trioxide (ATO)
Transcriptional profiling of human leukemia?HL-60 cells comparing ATRA treated HL-60 cells with ATRA plus ATO. Goal was to determine the effects of ATO on ATRA induced differentiation of HL-60 cells. Two-condition experiment, ATRA vs. ATRA plus ATO treated HL-60 cells.
ORGANISM(S): Homo sapiens 
2015-03-31 | E-GEOD-67420 | biostudies-arrayexpress
ProteomicsShotgun mass-spectrometry of HL-60 cell proteins for spectrum library development
ATRA-induced differentiation of HL-60 cells was studied using targeted mass-spectrometry including selected reaction monitoring (SRM) and parallel reaction monitoring (PRM) approach. PRM experiment was performed in time-course manner, without peptide standards usage. PRM data was inspected in Skylin...
ORGANISM(S): Homo sapiens (Human) 
2017-11-09 | PXD006421 | Pride
Orbitrap velos Atra Differentiation Hl-60 cell line 
TranscriptomicsRNA-seq of HL-60 cells before and after differentiation and upon a BAR domain protein Snx33 knockout
RNA-seq was performed to access the differences in transcriptome profiling of neutrophil-like HL-60 cells pre- and 5 days post-differentiation and upon BAR domain protein knockout (post-differentiation). Samples were collected before or after 5 days of differentiation with 1.5% DMSO for wild-type HL...
ORGANISM(S): Homo sapiens 
2023-06-20 | E-MTAB-12436 | biostudies-arrayexpress
GenomicsHomo sapiens strain:HL-60
Homo sapiens strain:HL-60 Transcriptome or Gene expression
PRJNA239705 | ENA
TranscriptomicsGene expression patterns in response to GATA2 (WT and mutants) in HL-60 cells
GATA2 mutants were discovered in families predisposed to MDS/AML and in sporadic cases of CML-blast crisis. Promyelocytic HL-60 cells were transduced with lentiviral vectors that express GATA2 WT or T354M, 355delT or L359V mutants upon addition of 4-hydroxy tamoxifen (4HT). Microarrays were performe...
ORGANISM(S): Homo sapiens 
2011-08-19 | E-GEOD-29276 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of neutrophils from CD40L-deficient patients and healthy controls, as well as HL-60 promielocytic cell line
We aim to characterize to effects of the absence of CD40L on neutrophil transcriptome and the effect of soluble CD40L on HL60 cells. For this purpose Total RNA of isolated neutrophils from three CD40L-deficient patients and three healthy controls as well as HL-60 cells from ATCC (HL-60 (ATCC CCL-240...
ORGANISM(S): Homo sapiens 
2017-03-14 | E-MTAB-5316 | biostudies-arrayexpress
TranscriptomicsEffects of supernatants of USP2 knockdown HL-60 cells and mock transfected HL60 cells on differentiated 3T3-L1 cells
Ubiquitin specifc protease (USP) 2 modulates various cellular responces including carcinogenesis, spermatogenesis, and glucose metabolism. So far, we established USP2 knockdown HL-60 cells to explore roles of USP2 in macrophages. In this experiment, we investigated whether USP2 knockdown HL-60 cells...
ORGANISM(S): Mus musculus 
2013-08-27 | E-GEOD-43313 | biostudies-arrayexpress
GenomicsEpichromatin HL-60/S4
Epichromatin HL-60/S4
PRJEB5782 | ENA
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