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ProteomicsThe landscape of the SARS-CoV-2 HLA-peptidome
The human leukocyte antigen (HLA)-bound-viral antigens, serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of viral presented antigens. Utilizing HLA-peptidomics we Identified SARS-CoV-2-der...
ORGANISM(S): Homo sapiens (Human) 
2021-06-28 | PXD025499 | Pride
Sars-cov-2 Immunopeptidomics Hla-peptidomics 
Proteomicsthe landscape of phosphorylated HLA-I ligands
The identification and prediction of HLA-I–peptide interactions play an important role in our understanding of antigen recognition in infected or malignant cells. In cancer, non-self HLA-I ligands can arise from many different alterations, including non-synonymous mutations, gene fusion, cancer-spec...
ORGANISM(S): Homo sapiens (Human) 
2019-12-18 | PXD013831 | Pride
Immunopeptidomics Hla binding peptides Phosphorylations 
ProteomicsUnsupervised mining of HLA-I peptidomes reveals unsuspected false positives and new binding motifs
Modern antigen vaccine designs and studies of human leukocyte antigen (HLA)-mediated immune responses rely heavily on the knowledge of HLA allele-specific binding motifs and computational prediction of antigen-HLA binding affinity. Breakthroughs in HLA peptidomics have considerably expanded the data...
ORGANISM(S): Homo sapiens (Human) 
2021-09-17 | PXD028088 | Pride
Smsnet Peptidome Hla-i 
ProteomicsIdentification of HLA-A*11:01 and A*02:01-restricted EBV Pep-tides using HLA Peptidomics
Identification of HLA-A*11:01 and A*02:01-restricted EBV Pep-tides using HLA Peptidomics
ORGANISM(S): Homo sapiens (Human) 
2024-06-14 | PXD051538 | Pride
Immunopeptidome 
ProteomicsHLA-I peptidomics od Meningioma tissues - Peptide length distribution and multiple specificity in naturally presented HLA-I ligands
HLA-I molecules bind short peptides and present them to CD8+ T cells for TCR recognition. The length of HLA-I ligands typically ranges from 8 to 12 amino acids, but high variability is observed between different alleles. Here we used recent HLA peptidomics data to analyze in an unbiased way peptide ...
ORGANISM(S): Homo sapiens (Human) 
2019-07-31 | PXD009925 | Pride
Hla binding motifs Hla class i peptides Meningioma 
ProteomicsIdentification of microbial-derived HLA-bound peptides in melanoma
Various bacterial species are known to colonize human tumors , proliferate within them and modulate immune function, ultimately affecting patient survival and response to treatment. However, it is not known whether intracellular bacterial antigens are presented by HLA-I and HLA-II molecules of tumor...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD022150 | Pride
Human Lc-msms Hla peptidomics Microbiome Immunopeptidomics 
ProteomicsFully unsupervised identification of HLA-I motifs
The precise identification of Human Leukocyte Antigen class I (HLA-I) binding motifs plays a central role in our ability to understand and predict (neo-)antigen presentation in infectious diseases and cancer. Here, by exploiting co-occurrence of HLA-I alleles across publicly available as well as ten...
ORGANISM(S): Homo sapiens (Human) 
2017-08-18 | PXD005231 | Pride
Hla peptidome Immunopeptidomics Lc-ms/ms 
ProteomicsHLA peptides (LC-MSMS) induced by Decitabine in Glioblastoma cell lines
Treatment of cancer cells with anti-cancer drugs often fails to achieve complete remission. Yet, such drug treatments may induce alteration in the tumor’s gene expression patterns, including those of Cancer/Testis Antigens (CTA). The degradation products of such antigens can be presented as HLA pept...
ORGANISM(S): Homo sapiens (Human) 
2016-07-18 | PXD003790 | Pride
Decitabine Glioblastoma Hla peptides 
ProteomicsThe landscape of the SARS-CoV-2 HLA-peptidome
The human leukocyte antigen (HLA)-bound-viral antigens, serve as an immunological signature that can be selectively recognized by T cells. As viruses evolve by acquiring mutations, it is essential to identify a range of viral presented antigens. Utilizing HLA-peptidomics we Identified SARS-CoV-2-der...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-11-01 | MSV000088298 | MassIVE
ProteomicsIdentification of tumor antigens among the HLA peptidomes of Glioblastoma tumors and plasma
Glioblastoma multiforme (GBM) is the most aggressive brain tumor with poor prognosis to most patients. Immunotherapy of GBM is a potentially beneficial treatment option, whose optimal implementation may depend on familiarity with tumor specific antigens, presented as HLA peptides by the GBM cells. F...
ORGANISM(S): Homo sapiens (Human) 
2019-06-11 | PXD008127 | Pride
Hla peptidome Shla Mhla Glioblastoma Plasma Early detection 
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