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TranscriptomicsRNA-seq of HLA-A2 restricted human CD8+ T cells against SARS-CoV-2 from 11 COVID-19 patients
A cryovial that contains frozen PBMCs (10^6 cells/vial) from each of 11 COVID-19 patients was thawed in 37oC water bath. Immediately after, thawed cells were transferred to 15-mL Falcon tube that contained 10 mL of cold culture medium. After centrifugation at 150g for 5 min, the cell pellets were r...
ORGANISM(S): Homo sapiens 
2025-12-01 | E-MTAB-14727 | biostudies-arrayexpress
ProteomicsImmunopeptidomic profiling of HLA-A2-positive triple negative breast cancer
Here we analysed the immunopeptidomes of 6 HLA-A2-positive triple negative breast cancer (TNBC) samples by nano-ultra performance liquid chromatography tandem mass spectrometry (nUPLC-MS2).
ORGANISM(S): Homo sapiens (Human) 
2018-06-29 | PXD009738 | Pride
Hla-a2 Immunopeptidomics Tnbc 
ProteomicsH3.3K27M HLA-A2 is not an effective immunotherapy target for diffuse midline glioma
The study investigated presentation of HLA A2 restricted H3.3K27M neopeptide using immunopeptidomics followed by DDA and/or targeted multiple monitoring reaction (MRM).
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD038371 | Pride
Hla Car t cells H3.3 k27m Dipg Immunopeptidomics 
GenomicsxGVHD in NSG and NSG-HLA-A2/HHD mice
Xenogeneic graft-versus-host disease in humanized NSG and NSG-HLA-A2/HHD mice
PRJEB26672 | ENA
TranscriptomicsRNA-Seq of T cells sorted from human PBMCs, or from T cells stimulated with CD3/CD28 beads for 4 days, or from the spleen of NSG or NSG-HLA-A2/HHD mice, 7 days after transplantation with human PBMCs
The goal of the experiment is to describe the overall transcriptomic alterations and signaling pathways activated by T cells upon transplantation in NSG or NSG-HLA-A2/HHD mice. PBMCs and CD3/CD28 activated T cells serve as negative and positive controls of these pathways activation, respectively. PB...
ORGANISM(S): Homo sapiens 
2018-08-14 | E-MTAB-6865 | biostudies-arrayexpress
TranscriptomicsComparison of gene expression profiles by CD3+CD4+ thymocytes derived from fetal and adult hematopoietic stem cells
Human fetal and adult hematopoietic stem cells (HSC) were obtained from fetal liver, fetal bone marrow (BM), and adult BM. These were injected into human fetal thymic implants in SCID-hu Thy/Liv mice (4-6 separate mice per HSC donor) and allowed to mature into single positive CD4+ (SP4) thymocytes o...
ORGANISM(S): Homo sapiens 
2010-12-17 | E-GEOD-25085 | biostudies-arrayexpress
ProteomicsA library of novel Cancer Testis specific T cell receptors for T cell receptor gene therapy
Background Clinical success of T cell receptor (TCR) gene therapy has previously been demonstrated for NY-ESO-1 TCR gene therapy. To increase numbers of cancer patients that can be treated with TCR gene therapy we aimed to identify a novel set of high-affinity cancer specific TCRs targeting differen...
ORGANISM(S): Homo sapiens (Human) 
2023-01-23 | PXD038862 | Pride
T cell receptor Tcr gene therapy Mage Cd8+ t cells Cancer testis genes 
UnknownCharacterization of immunologic properties of a second HLA-A2 epitope from a granule protease in CML patients and HLA-A2 transgenic mice.
Not available
S-EPMC3162352 | biostudies-literature
GenomicsRNA-seq of HLA-A2 restricted human CD8+ T cells against SARS-CoV-2 from 11 COVID-19 patients
RNA-seq of HLA-A2 restricted human CD8+ T cells against SARS-CoV-2 from 11 COVID-19 patients
PRJEB83834 | ENA
UnknownAnti-HLA-A2-CAR Tregs prolong vascularized mouse heterotopic heart allograft survival.
Not available
S-EPMC9427704 | biostudies-literature
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