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ProteomicsQuantification of cellular protein and redox imbalance using SILAC-iodoTMT methodology
A new analytical method capable of simultaneously assessing cellular protein expression and cysteine oxidation would provide a valuable tool for the field of cysteine-targeted biology. Here, we show a workflow based on protein quantification using metabolic labeling and determination of cysteine oxi...
ORGANISM(S): Homo sapiens (Human) 
2026-09-03 | PXD012504 | Pride
Cysteine Liquid chromatography/mass spectrometry Silac-iodotmt labeling Peroxiredoxin Proteome Redoxome 
ProteomicsPeroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape, secretome analysis
Cellular senescence is a complex stress response defined as an essentially irreversible cell cycle arrest mediated by the inhibition of cell cycle-specific cyclin dependent kinases. The imbalance in redox homeostasis and oxidative stress have been repeatedly observed as one of the hallmarks of the s...
ORGANISM(S): Homo sapiens (Human) 
2022-02-16 | PXD028772 | Pride
Secretome analysis Peroxiredoxin 6 Cellular senescence Dia Exploris Ionizing radiation 
TranscriptomicsTranscriptome analysis of JAK2wt and JAK2V617F+ iPSCs and iPSC-derived CD34+ progenitor-enriched cultures, either inflammatory cytokines treated or untreated.
PV-patient specific and control healthy individual-derived iPSCs were upon differentiation for 9 days into CD34+ hematopoietic progenitors treated with IFNγ, TNFα and TGFβ1 or untreated and used for transcriptome analysis. This dataset shows presence of cell-autonomous and strong non-cell autonomous...
ORGANISM(S): Homo sapiens 
2020-12-03 | E-MTAB-7693 | biostudies-arrayexpress
UnknownPeroxiredoxin 6 protects irradiated cells from oxidative stress and shapes their senescence-associated cytokine landscape.
Not available
S-EPMC8688892 | biostudies-literature
UnknownQuantification of cellular protein and redox imbalance using SILAC-iodoTMT methodology.
Not available
S-EPMC6545335 | biostudies-literature
ProteomicsCellular senescence escape and antiviral response discriminate glioblastoma from lower grade gliomas
Cellular senescence is a negative prognostic indicator in glioblastoma (GB). However, the specific cell types exhibiting senescence and the molecular mechanisms by which senescent cells (SCs) contribute to GB pathogenesis remain unknown. We performed multi-omics integration of publicly available GB ...
ORGANISM(S): Homo sapiens (Human) 
2026-06-08 | PXD071225 | Pride
UnknownSuprabasin-A Review.
Not available
S-EPMC7831088 | biostudies-literature
UnknownClusterin Deficiency Promotes Cellular Senescence in Human Astrocytes.
Not available
S-EPMC11953114 | biostudies-literature
UnknownComplementary genetic screens identify the E3 ubiquitin ligase CBLC, as a modifier of PARP inhibitor sensitivity.
Not available
S-EPMC4484416 | biostudies-literature
UnknownSynergism of BCL-2 family inhibitors facilitates selective elimination of senescent cells.
Not available
S-EPMC9467395 | biostudies-literature
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