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ProteomicsThe fitness cost of spurious phosphorylation
The fidelity of signal transmission requires the binding of regulatory molecules to their cognate targets. However, the crowded cell interior risks off-target interactions between proteins that are functionally unrelated. Understanding the constraints this imposes on cell systems evolution requires ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2024-09-12 | PXD045466 | Pride
Spurious Human Lcms Phosphotyrosine Yeast 
ProteomicsBenchmarking LFQ, SILAC and MS2/MS3-based TMT quantification strategies for large-scale phosphoproteomics
Comprehensive mass spectrometry (MS)-based proteomics is now feasible, but reproducible and multiplexed quantification remains challenging especially for analysis of post-translational modifications (PTMs), such as phosphorylation. Here we compared the most popular quantification techniques for phos...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2018-03-13 | PXD007145 | Pride
Phosphoproteomics Ms3 Ms2 Tmt Silac Lfq Technical Benchmark Quantification 
ProteomicsEuPA YPIC challenge entry - proteome data analysis
Sweet Google O’ Mine - The Importance of Online Search Engines for MS-facilitated, Database-independent Identification of Peptide-encoded Book Prefaces
ORGANISM(S): artificial sequences 
2019-10-29 | PXD007693 | Pride
Maxquant de novo Eupa ypic challenge Synthetic peptides 
ProteomicsIsobaricQuant enables cross-platform quantification, visualization, and filtering of isobarically-labeled peptides
In mass spectrometry (MS)-based quantitative proteomics, labeling with isobaric mass tags such as iTRAQ and TMT can substantially improve sample throughput and reduce peptide missing values. Nonetheless, the quantification of labeled peptides tends to suffer from reduced quantitative accuracy due to...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2022-07-11 | PXD034534 | Pride
Reanalysis 
UnknownThe recurrent missense mutation p.(Arg367Trp) in YARS1 causes a distinct neurodevelopmental phenotype.
Not available
S-EPMC8599376 | biostudies-literature
UnknownPontocerebellar hypoplasia due to bi-allelic variants in MINPP1.
Not available
S-EPMC7940488 | biostudies-literature
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