Sort   by:  
 Page size 
TranscriptomicsExpression data from a reversible dasatinib-resistant state in long-term dasatinib-treated c-KIT-mutated Kasumi-1 cell line
Long-term treatment of Kasumi-1 cells at clinically attained doses of dasatinib led to decreased drug-sensitivity by means of IC50 values (relative to treatment-naive cells). Changes were paralled by profound alterations in c-KIT expression and cell signaling signatures. Upon brief discontinuation o...
ORGANISM(S): Homo sapiens 
2013-11-27 | E-GEOD-39073 | biostudies-arrayexpress
TranscriptomicsHigh-resolution genomic profiling of marginal zone B-cell lymphomas and variants
We studied marginal zone B-cell lymphomas of the gastrointestinal tract including seven small cell MALT lymphomas, eight composite lymphomas and thirteen large cell variants using SNP-array profiling. We found an increase of genomic complexity with lymphoma progression, and could identify gains of p...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-36311 | biostudies-arrayexpress
TranscriptomicsCharacterization of Formaldehyde's Genotoxic Mode of Action by Gene Expression Analysis in TK6 Cells
Gene expression analysis has been established as a tool for the characterization of genotoxic mechanisms of chemical mutagens. This approach has been shown to differentiate between DNA reactive genotoxins and non-DNA reactive or indirectly-acting genotoxins. In this context, it has been suggested th...
ORGANISM(S): Homo sapiens 
2013-05-13 | E-GEOD-41296 | biostudies-arrayexpress
ProteomicsAbsolute quantification of cohesin and its regulators in human cells
The organisation of mammalian genomes into loops and topologically associated domains (TADs) regulates gene expression. The formation and maintenance of loops and TADs depends on the protein complex cohesin, which also holds replicated sister chromatids together from S phase until mitosis. To unders...
ORGANISM(S): Homo sapiens (Human) 
2019-11-13 | PXD012712 | Pride
Fluorescence-correlation spectroscopy Mass spectrometry Cell cycle Genome organization Cohesin Sister chromatid cohesion 
TranscriptomicsIdentification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant
This SuperSeries is composed of the following subset Series: GSE27512: Identification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (miRNA) GSE27513: Identification of a Potently Oncogenic CALM-AF10 Minimal-Fusion Mutant (mRNA) Refer to individual Series
ORGANISM(S): Mus musculus 
2011-10-04 | E-GEOD-27514 | biostudies-arrayexpress
UnknownEarly Risk of Stroke in Patients Undergoing Acute Versus Elective Cardioversion for Atrial Fibrillation.
Not available
S-EPMC8475048 | biostudies-literature
TranscriptomicsExpression of constitutively active FOXO3 in murine forebrain leads to a loss of neural progenitors
We have generated transgenic mice with tetracycline-regulated conditional expression of a constitutively active allele of FoxO3 under the control of the forebrain-specific CaMKIIa promoter. In adult animals, there was a reduction of brain weight by 30% and an almost complete loss of the dorsal denta...
ORGANISM(S): Mus musculus 
2012-09-13 | E-GEOD-21089 | biostudies-arrayexpress
TranscriptomicsExamination of tumor samples obtained after laparoscopic supracervical hysterectomy and a derivative leiomyosarcoma
Unexpected malignant tumors are a rare finding after surgery for symptomatic leiomyomas but there is little doubt that morcellation of these lesions is associated with a higher risk of iatrogenic peritoneal spread compared to women having surgery without morcellation. Thus, the FDA has issued a warn...
ORGANISM(S): Homo sapiens 
2018-04-30 | E-MTAB-6039 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution Genomic Profiling of Chronic Lymphocytic Leukemia Reveals New Recurrent Genomic Alterations
To identify genomic alterations in chronic lymphocytic leukemia (CLL), we performed single-nucleotide polymorphism (SNP)-array analysis on 353 samples from previously untreated patients entered on the CLL8 treatment trial. Based on paired-sample analysis (n=147), a mean of 1.8 copy number alteration...
ORGANISM(S): Homo sapiens 
2012-10-11 | E-GEOD-36908 | biostudies-arrayexpress
UnknownUnveiling Small Non-Coding RNA Dynamics During Recombinant Adeno-Associated Virus Production.
Not available
S-EPMC12329270 | biostudies-literature
Sort   by:  
 Page size