Sort   by:  
 Page size 
ProteomicsBDNF BONLAC in HEK cells
In-depth Quantitative Proteomic Analysis of De Novo Protein Synthesis Induced by Brain-derived Neurotrophic Factor
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2014-08-26 | MSV000078831 | MassIVE
TranscriptomicsFast and chronic ethanol tolerance - time course
To better understand the molecular mechanisms underlying ethanol action we have developed an assay system to study sensitivity and fast and chronic tolerance to the sedative effects of ethanol. Flies developed fast ethanol tolerance after single exposure to 50% of ethanol vapor for 40 min. Flies ca...
ORGANISM(S): Drosophila melanogaster 
2006-03-24 | E-GEOD-4531 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat heart and adipose tissue response to aging and caloric restriction in
Sustained caloric restriction (CR) extends lifespan in animal models but the mechanism and primary tissue target(s) have not been identified. Gene expression changes with aging and CR were examined in both heart and subcutaneous white adipose tissue (WAT) of F344 male rats using Affymetrix® RAE 230...
ORGANISM(S): Rattus norvegicus 
2008-06-15 | E-GEOD-6718 | biostudies-arrayexpress
GenomicsThe PIAS-like coactivator Zmiz1 directly and selectively coregulates Notch1 in T-cell development and leukemia [ChIP-Seq]
The most recurrently mutated oncogene in T-cell acute lymphoblastic leukemia (T-ALL) is NOTCH1. The core Notch complex consists of an ICN protein, a Maml cofactor, and the DNA binding factor Rbpj. The known direct cofactors of Notch appear to act nonselectively, homogeneously driving Notch gene expr...
ORGANISM(S): Mus musculus 
2015-10-28 | E-GEOD-66146 | biostudies-arrayexpress
TranscriptomicsRNA-Seq profiling unveils a non-canonical Wnt signalling signature in pancreas versus liver fate decision
Understanding how distinct cell types arise from common multipotent progenitor cells is a major quest in stem cell biology. This knowledge will aid in the targeted differentiation and growth of stem cells, but also in the discovery of the basis of cellular plasticity and of how tissue programming ca...
ORGANISM(S): Mus musculus 
2013-09-11 | E-GEOD-40823 | biostudies-arrayexpress
TranscriptomicsExpression of virulent and non-virulent E.histolytica in contact with the human colon
Evaluation of transcript levels of two strains E.Histolytica (virulent and avirulent) in two conditions (in culture or in contact with a human colon explant)
ORGANISM(S): Entamoeba histolytica 
2012-08-01 | E-MTAB-1201 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Saccharomyces cerevisiae knock-outs of non-essential chromatin modifiers
Non-essential knockouts of chromatin modifiers have been investigated by expression profiling.
ORGANISM(S): Saccharomyces cerevisiae 
2011-08-05 | E-TABM-1074 | biostudies-arrayexpress
TranscriptomicsHigh-throughput sequencing of endogenous small RNAs from rat vascular smooth muscle cells with and without Angiotensin II stimulation
Angiotensin II (Ang II)-mediated vascular smooth muscle cells (VSMC) dysfunction plays a critical role in cardiovascular diseases. However, the role of microRNAs (miRNAs) in this process is unclear. We used small RNA deep sequencing to profile Ang II-regulated miRNAs in rat VSMC and evaluated their ...
ORGANISM(S): Rattus norvegicus 
2012-03-23 | E-GEOD-35664 | biostudies-arrayexpress
GenomicsThe RUNX2 Cistrome in Osteoblasts: Characterization, Downregulation Following Differentiation and Relationship to Gene Expression [ChIP-Seq]
RUNX2 is a transcription factor that is first expressed in early osteoblast-lineage cells and represents a primary determinant of osteoblastogenesis. While numerous target genes are regulated by RUNX2, little is known of sites on the genome occupied by RUNX2 or of the gene networks that are control...
ORGANISM(S): Mus musculus 
2014-04-24 | E-GEOD-41920 | biostudies-arrayexpress
GenomicsGenomic Determinants of Gene Regulation by 1,25-Dihydroxyvitamin D3 During Osteoblast-Lineage Cell Differentiation [ChIP-Seq]
The biological effects of 1?,25-dihydroxyvitamin D3 (1,25(OH)2D3) on osteoblast differentiation and function differ significantly depending upon the cellular state of maturation. To explore this phenomenon mechanistically, we examined the impact of 1,25(OH)2D3 on the transcriptomes of both pre-oste...
ORGANISM(S): Mus musculus 
2014-06-02 | E-GEOD-51513 | biostudies-arrayexpress
Sort   by:  
 Page size