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ProteomicsCaMKK2 Inactivation by cAMP-PKA Signaling and 14-3-3 Adaptor Proteins
The calcium-calmodulin (Ca2+-CaM) dependent protein kinase kinase-2 (CaMKK2) is activated by increases in intracellular Ca2+ and is a key regulator of cellular and wholebody energy metabolism. CaMKK2 inhibition protects against prostate cancer, hepatocellular carcinoma and metabolic derangements ind...
ORGANISM(S): Homo sapiens (Human) 
2020-11-06 | PXD020133 | Pride
Cyclic amp (camp) Calcium-calmodulin (ca2+-cam) dependent protein kinase kinase-2 (camkk2) Protein kinase a (pka) 14-3-3 adaptor proteins 
ProteomicsDynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons
Excitotoxicity caused by over-stimulation of the ionotropic glutamate receptors is a key neuronal cell death process underpinning brain damage in acute and chronic neurological disorders such as ischaemic stroke, traumatic brain injury, and neurodegenerative diseases. Exactly how neurons die in exci...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-07 | PXD008353 | Pride
Neuron Phosphoproteome Proteome Excitotoxicity 
ProteomicsQuantitative global and phosphoproteomic analysis to define the cellular role of AMPK β1-Ser108 phosphorylation
AMP-activated protein kinase (AMPK) is a metabolic stress-sensing enzyme responsible for maintaining cellular energy homeostasis. Activation of AMPK by salicylate and the thienopyridone A-769662 is critically dependent on phosphorylation of Ser108 in the β1 regulatory subunit. We identified the auto...
ORGANISM(S): Mus musculus (Mouse) 
2018-10-24 | PXD006365 | Pride
Autophagy Ulk1 Ampk β1-ser108 
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