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ProteomicsInflammasome-independent IL-1β activation via staphopain A protease of Staphylococcus aureus
Interleukin-1β (IL-1β) is a pivotal mediator of innate immunity, essential for orchestrating the acute inflammatory response. While the canonical activation of IL-1β involves cleavage of its inactive precursor (pro-IL-1β) by the inflammatory cysteine protease caspase-1, certain bacterial proteases, ...
ORGANISM(S): Staphylococcus aureus 
2025-10-27 | PXD057289 | Pride
Keratinocytes Inflammasome Interleukin-1β Staphopain a Staphylococcus aureus Microbial proteases Nlrp1 
ProteomicsPriming by IKKβ recruits NLRP3 to the trans-Golgi network to enable NEK7-independent inflammasome activation
The NLRP3 inflammasome plays a central role in antimicrobial defense as well as in the context of sterile inflammatory conditions. NLRP3 activity is governed by two independent signals: The first signal primes NLRP3, rendering it responsive to the second signal, which then triggers inflammasome form...
ORGANISM(S): Mus musculus (Mouse) 
2022-11-17 | PXD035302 | Pride
Human Lc-msms Macrophages Monocytes Innate immunity Nek7 Pattern recognition Inflammasome Nlrp3 
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