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MetabolomicsPathogenic NLRP3 mutants form constitutively active inflammasomes resulting in immune-metabolic limitation of IL-1β production

BACKGROUND: Cryopyrin-Associated Periodic Syndrome (CAPS) is an autoinflammatory condition consequence of monoallelic variants in the NLRP3 gene that exacerbate IL-1β production. These variants are gain-of-function, but the exact regulatory mechanism of the NLRP3 CAPS-inflammasom...

2024-01-09 | MTBLS7872 | MetaboLights
ProteomicsOxidized thioredoxin-1 restrains the NLRP1 inflammasome
To find cellular protein binding partners of the NLRP1 inflammasome, FLAG-tagged full length NLRP1 (or a GFP-FLAG protein control) was ectopically expressed in HEK 293T cells and affinity purified from cell lysates (Note: the NLRP1-FLAG-containing lysate samples were affinity purified in the presenc...
ORGANISM(S): Homo sapiens (Human) 
2022-11-04 | PXD037391 | Pride
Innate immunity Programmed cell death Inflammasome Chemical biology Pattern recognition receptors 
ProteomicsThe interaction between NLRP1 and oxidized TRX1 involves a transient disulfide bond: LC-MS/MS Dataset
LC-MS/MS analysis of a gel slice containing a disulfide-cross-linked peptide chains between thioredoxin-1 and the NACHT-LRR domains of NLRP1
ORGANISM(S): Homo sapiens (Human) 
2025-05-26 | PXD047547 | Pride
Disulfide Lc-ms Nlrp1 Trx1 
GenomicsOxidized thioredoxin-1 restrains the NLRP1 inflammasome [mBMDM]
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome [mBMDM]
PRJNA888114 | ENA
GenomicsOxidized thioredoxin-1 restrains the NLRP1 inflammasome [NTERT-1]
Oxidized thioredoxin-1 restrains the NLRP1 inflammasome [NTERT-1]
PRJNA888113 | ENA
TranscriptomicsOxidized thioredoxin-1 restrains the NLRP1 inflammasome [mBMDM]
The danger signals that activate the NLRP1 inflammasome have yet to be firmly established. NLRP1 undergoes autoproteolysis to generate N-terminal (NT) and C-terminal (CT) fragment, which importantly, is a necessary step for its check-point regulation by the DPP9 ternary complex and the mechanistic a...
ORGANISM(S): Mus musculus 
2022-11-04 | GSE215035 | GEO
TranscriptomicsOxidized thioredoxin-1 restrains the NLRP1 inflammasome [NTERT-1]
The danger signals that activate the NLRP1 inflammasome have yet to be firmly established. NLRP1 undergoes autoproteolysis to generate N-terminal (NT) and C-terminal (CT) fragment, which importantly, is a necessary step for its check-point regulation by the DPP9 ternary complex and the mechanistic a...
ORGANISM(S): Homo sapiens 
2022-11-04 | GSE215034 | GEO
GenomicsNLRP1 inflammasome activation in skin equivalents reveals mechanistic insights into the roles of keratinocytes in psoriasis
NLRP1 inflammasome activation in skin equivalents reveals mechanistic insights into the roles of keratinocytes in psoriasis
PRJNA1187582 | ENA
ProteomicsGenomic contamination causes NLRP1 hypersensitivity and altered cell surface markerGenomic contamination causes NLRP1 hypersensitivity and altered cell surface marker expression in Nlrp3-/- macrophagesGenomic contamination causes NLRP1 hypersensitivity and altered cell surface marker expression in Nlrp3-/- macrophages
The NLRP1 and NLRP3 inflammasomes are critical immune signaling hubs that drive cytokine release and inflammatory cell death, and have been implicated in the pathogenesis of diverse diseases. Much of our understanding of inflammasome biology stems from experiments performed in transgenic mouse lines...
ORGANISM(S): Mus musculus (Mouse) 
2024-09-16 | PXD046782 | Pride
Inflammasome Mouse genetics Immunology 
UnknownNLRP1- A CINDERELLA STORY: a perspective of recent advances in NLRP1 and the questions they raise.
Not available
S-EPMC10725483 | biostudies-literature
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