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TranscriptomicsComparative genomic hybridization of mouse adapted strains of Helicobacter pylori
Microarray based comparative genomic hybridization of mouse adapted strains: 10700 pre-mouse SS1, SS1(A.L.)Sydney strain obtained directly from Adrian Lee, NSH79 Salama lab strain labeled as SS1-now know distinct, G27 obtained from Antonello Covacci. Genomic DNA from est strain (Cy5), genomic DNA fr...
ORGANISM(S): Helicobacter pylori 
2006-12-15 | E-SMDB-3902 | biostudies-arrayexpress
TranscriptomicsMouse MOV10L1 associates with Piwi proteins and is an essential component of the piRNA pathway
Piwi-interacting RNAs (piRNAs) are essential for silencing of transposable elements in the germline but their biogenesis is poorly understood. Here we demonstrate that MOV10L1, a germ cell-specific putative RNA helicase, is associated with Piwi proteins. Genetic disruption of the MOV10L1 RNA helicas...
ORGANISM(S): Mus musculus 
2010-06-12 | E-GEOD-21763 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse fibroblast cells transfected with zinc-inducible C/EBP expression vectors identifies Per2 as a gene implicated in myeloid leukemia
The zinc-inducible C/EBP expression vectors pMTa, pMTb, pMTd and pMTe were constructed by cloning the human C/EBPa, C/EBPb, C/EBPd and C/EBPe cDNAs, respectively, into the pMTCB6+ vector. NIH 3T3 cells were transfected with zinc-inducible C/EBP vectors as well as control empty vector using the GeneP...
ORGANISM(S): Mus musculus 
2007-12-04 | E-GEOD-2188 | biostudies-arrayexpress
GenomicsIL-10 production and metabolic regulation in macrophages are linked by a TLR-driven CREB-mediated mechanism
IL-10 is produced by macrophages in diverse immune settings and is critical in limiting immune-mediated pathology. In helminth infections macrophages are an important source of IL-10, however the molecular mechanism underpinning production of IL-10 by these cells is poorly characterized. Here, bone ...
ORGANISM(S): Mus musculus 
2015-07-08 | E-GEOD-64844 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of chloride channel ClC-2 knock out mice with a Leukoencephalopathy-like phenotype vs.wild type
ClC-2 is a broadly expressed Cl- channel of the CLC family of Cl- channels and transporters which is abundantly expressed in brain. Here it was proposed to participate in lowering the cytoplasmic Cl- concentration of neurons, a process that establishes an inhibitory response to the neurotransmitters...
ORGANISM(S): Mus musculus 
2008-05-01 | E-MEXP-1028 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse liver treated with phenobarbital and fed a high cholesterol diet an
High cholesterol diet and xenobiotic treatment induce changes in cholesterol homeostasis and drug metabolism. Mice were either 7 days on high cholesterol diet or were treated with phenobarbital. Liver samples were anayzed using Affymetrix GeneChip MOE430A. Experiment Overall Design: One group of mic...
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-6721 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expressions in vivo by anti-VEGF therapy
U87-EV human glioblastoma xenograft tumours is therapeutically treated by bevacizumab, a humanized anti-human VEGF mAb, when tumour is established in BALB/c SCID mice. At the end point, collect tumour samples and extracted total RNA for microarray to investigate the gene profile changes compared to ...
ORGANISM(S): Homo sapiens 
2014-04-25 | E-GEOD-37956 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse B cells from wild type or mir-155 deficient mice, treated with a-mir155 PNA
B cells were extracted from spleens of mice treated with PNA a-miR155 and vehicle treated mice either wild type or mir-155 deficient. All mice received LPS to induce mir155 expression.
ORGANISM(S): Mus musculus 
2010-03-24 | E-MEXP-2587 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expressions in vivo by anti-VEGF and anti-Notch therapy [Mouse430_2]
U87-EV human glioblastoma xenograft tumours is therapeutically treated by bevacizumab, a humanized anti-human VEGF mAb, or dibenzazepine (DBZ) when tumour is established in BALB/c SCID mice. At the end point, collect tumour samples and extracted total RNA for microarray to investigate the gene profi...
ORGANISM(S): Mus musculus 
2014-04-25 | E-GEOD-39413 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expressions in vivo by anti-VEGF and anti-Notch therapy [HG-U133_Plus_2]
U87-EV human glioblastoma xenograft tumours is therapeutically treated by bevacizumab, a humanized anti-human VEGF mAb, or dibenzazepine (DBZ), when tumour is established in BALB/c SCID mice. At the end point, collect tumour samples and extracted total RNA for microarray to investigate the gene prof...
ORGANISM(S): Homo sapiens 
2014-04-25 | E-GEOD-39223 | biostudies-arrayexpress
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