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ProteomicsHOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway via stimulating MSK1 kinase and suppressing PPP2R2B protein
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective therapies. We demonstrated that the transcription factor, HOXC6, was overexpressed in most PDACs, and its inhibition blocked PDAC tumor growth and metastasis. HOXC6 transcriptionally activated the tumor-pr...
ORGANISM(S): Homo sapiens (Human) 
2023-10-31 | PXD041238 | Pride
Pancreatic cancer Hoxc6 Tumor growth Msk1 Metastasis 
ProteomicsHOXC6 drives a therapeutically targetable pancreatic cancer growth and metastasis pathway via stimulating MSK1 kinase and suppressing PPP2R2B protein
Pancreatic ductal adenocarcinoma (PDAC) is one of the deadliest cancers, which lacks effective therapies. We demonstrated that the transcription factor, HOXC6, was overexpressed in most PDACs, and its inhibition blocked PDAC tumor growth and metastasis. HOXC6 transcriptionally activated the tumor-pr...
ORGANISM(S): Homo sapiens (Human) 
2023-10-31 | PXD041239 | Pride
Pancreatic cancer Hoxc6 Tumor growth Msk1 Metastasis 
GenomicsHOXC6 affects the malignant phenotype of esophageal squamous cell carcinoma cells
HOXC6 affects the malignant phenotype of esophageal squamous cell carcinoma cells
PRJNA501870 | ENA
TranscriptomicssiRNA profiling of human LNCaP cells overexpressing/knockdown of HOXC6
The transcription factor HOXC6 is upregulated in human prostate cancer. SiRNA knockdown of HOXC6 induces apoptosis in LNCaP cells while upregulation rescued LNCaP cells from siRNA-induced apoptosis. We used microarrays to identify the genes whose expression underly the anti-apoptotic and proliferati...
ORGANISM(S): Homo sapiens 
2008-10-20 | E-GEOD-9182 | biostudies-arrayexpress
GenomicsEffect of HOXC6 deletion on gene expression in Ewing Sarcoma cell line RD-ES.
Effect of HOXC6 deletion on gene expression in Ewing Sarcoma cell line RD-ES.
PRJNA1097532 | ENA
GenomicsEvidence for HOXC6 as a potential molecular marker for non-small cell lung cancer
Evidence for HOXC6 as a potential molecular marker for non-small cell lung cancer
PRJNA499008 | ENA
TranscriptomicsHOXC6 affects the malignant phenotype of esophageal squamous cell carcinoma cells
HOXC6 is a member of the HOX family, and its aberrant expression has been verified in a variety of cancers, such as prostate, breast,nasopharyngeal carcinoma,gastric, and ovarian cancers.Some studies suggest that HOXC6 might be involved in tumor initiation and progression.However, the role of HOXC6 ...
ORGANISM(S): Homo sapiens 
2019-02-22 | GSE121976 | GEO
TranscriptomicsExpression data from overexpression and knockdown of HOXC6 in LNCaP cells
The transcription factor HOXC6 is upregulated in human prostate cancer. SiRNA knockdown of HOXC6 induces apoptosis in LNCaP cells while upregulation rescued LNCaP cells from siRNA-induced apoptosis. We used microarrays to identify the genes whose expression underly the anti-apoptotic and proliferati...
ORGANISM(S): Homo sapiens 
2008-07-01 | GSE9182 | GEO
GenomicsGenome-wide analysis of HOXC4 and HOXC6 regulated genes and binding sites in prostate cancer cells
Genome-wide analysis of HOXC4 and HOXC6 regulated genes and binding sites in prostate cancer cells
PRJNA533284 | ENA
TranscriptomicsEffect of HOXC6 deletion on gene expression in Ewing Sarcoma cell line RD-ES.
The early diagnosis of Ewing sarcoma (ES) is crucial for improving patient prognosis. This study has identified new diagnostic biomarkers for ES and evaluated the in vitro effect of HOXC6 on the RD-ES cell line. Experimental results demonstrated that HOXC6 knockout inhibited ES cell proliferation an...
ORGANISM(S): Homo sapiens 
2025-04-23 | GSE263430 | GEO
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