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TranscriptomicsHSF1 regulates transcription of sex-chromosomal multicopy genes during post-meiotic repression
Mapping of in vivo targets for HSF1 by using mammalian tissue material in a global ChIP-chip promoter screen. Chromatin was isolated from three wild-type (WT) mouse testes, crosslinked and sonicated into fragments of 100-500 bp, and the quality of the DNA was controlled before the immunoprecipitatio...
ORGANISM(S): Mus musculus 
2010-08-31 | E-GEOD-22492 | biostudies-arrayexpress
ProteomicsExcess protein synthesis, denatured proteins or molecular crowding spontaneously induce HSF1 trimerisation and activation
Stress responses are a key feature of normal physiology and are usurped by cancer cells to ensure enhanced protein synthesis for growth, to compensate for genomic instability, and to protect cancer cells from therapy induced stress. Heat shock factor-1 (HSF1) is a major stress-response transcription...
ORGANISM(S): Homo sapiens (Human) 
2024-08-14 | PXD037662 | Pride
Lc-msms Hsf1 Stress Hsp70 Hsp90 Crowding Hdx-ms Protein folding 
TranscriptomicsTranscription profiling of Candida albicans wild type and conditional mutant hsf1/TET-HSF1
To investigate the role of HSF1 in Candida albicans
ORGANISM(S): Candida albicans 
2010-01-05 | E-MEXP-1369 | biostudies-arrayexpress
TranscriptomicsEffect of 4-Hydroxynonenal on gene expression. Comparison of HSF1-siRNA silenced vs control cells
4-Hydroxynonenal (HNE), a cytotoxic and diffusible electrophile generated by the spontaneous decomposition of oxidized lipids, has a suspected role in neurodegenerative and inflammatory disease processes. In addition to promoting cell death, elevated levels of HNE lead to the engagement of cytoprote...
ORGANISM(S): Homo sapiens 
2010-09-15 | E-GEOD-12762 | biostudies-arrayexpress
GenomicsHSF1 Activation Can Restrict HIV Replication
HSF1 Activation Can Restrict HIV Replication
PRJNA565977 | ENA
TranscriptomicsTranscription profiling of Candida albicans wildtype and hsf1 mutant cells after heatstress
effect of heatstress on wildtype and hsf1 mutant cells
ORGANISM(S): Candida albicans 
2009-12-17 | E-MEXP-2044 | biostudies-arrayexpress
TranscriptomicsPolyglutamine expanded huntingtin dramatically alters the genome-wide binding of HSF1 (mRNA)
In Huntington's disease (HD), polyglutamine expansions in the huntingtin (Htt) protein cause subtle changes in cellular functions that, over-time, lead to neurodegeneration and death. Studies have indicated that activation of the heat shock response can reduce many of the effects of mutant Htt in d...
ORGANISM(S): Mus musculus 
2012-06-18 | E-GEOD-38001 | biostudies-arrayexpress
TranscriptomicsIdentification of genes up-regulated by the overexpression of HSF1 in human HeLa cells
To analyze target genes of human heat shock transcription factor 1 (HSF1), we first generated two independent HeLa clones (RDT1 and RDT2) expressing an actively mutated hHSF1 (hHSF1?RDT), which lacks the regulatory domain that masks its activation domain and possesses a glutamic acid at amino acid 3...
ORGANISM(S): Homo sapiens 
2010-09-22 | E-GEOD-19797 | biostudies-arrayexpress
TranscriptomicsExpression of heat shock factor 1 (HSF1) knock down (KD) in hepatocellular carcinoma (HCC) cells results in characteristic changes in gene expression profiles.
Analysis of HSF1-down regulation of HCC cells at gene expression level. Results provide important information of genes involved in HSF1, such as liver proliferation, apoptosis, stress response, metabolism, these genes were up- or down-regulated. Total RNA obtained from HSF1-KD KYN2 (HCC) cells and H...
ORGANISM(S): Homo sapiens 
2013-06-07 | E-GEOD-47693 | biostudies-arrayexpress
GenomicsTight coordination of protein translation and heat shock factor 1 activation supports the anabolic malignant state [ChIP-Seq]
A unifying characteristic of aggressive cancers is a profound anabolic shift in metabolism to enable sustained proliferation and biomass expansion. The ribosome is centrally situated to sense metabolic states but whether it impacts systems that promote cellular survival is unknown. Here, through ...
ORGANISM(S): Homo sapiens 
2013-07-21 | E-GEOD-45852 | biostudies-arrayexpress
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